Author

S. Le Noir

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:development & morphogenesis· 2 Assay:DNA methylation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. Carrion· 3 shared E. PINAUD· 3 shared M. Thomas· 3 shared C. Bruzeau· 2 shared J. Pollet· 2 shared M. Brousse· 2 shared O. Martin· 2 shared S. Bender· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersImmunology

C. Carrion

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4 papers

Recent·Most cited

Core enhancers of the 3'RR optimize IgH nuclear position and loop conformation for oriented CSR

C. Bruzeau, J. Pollet, M. Thomas, Z. Ba, D. Roulois, E. PINAUD, S. Le Noir

The paper shows that core enhancers of the IgH 3RR preorganize B cell nuclei to facilitate class switch recombination by controlling nuclear positioning and loop formation.

bioRxiv · Jul 11, 2023 · PreprintImmunology

A dual function for the chromatin organizer Special A-T rich Binding Protein 1 in B-lineage cells

M. Thomas, O. Martin, C. Bruzeau, J. Pollet, S. Bender, C. Carrion, S. Le Noir, E. Pinaud

This study investigates SATB1's role in B-lineage cells, finding it is not essential for B cell development but acts as both a positive and negative regulator of Ig gene transcription in naive and activated B cells, respectively.

bioRxiv · Sep 6, 2022 · PreprintImmunology

The IgH Eμ-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation

O. Martin, M. Thomas, M. Marquet, A. Garot, M. Brousse, S. Bender, C. Carrion, J. E. Choi, B. Vuong, P. Gearhart, R. Maul, S. Le Noir, E. Pinaud

The paper shows that IgH Eμ-MAR regions limit error-prone repair to the variable region of Ig genes by promoting UNG-dependent repair, affecting somatic hypermutation patterns.

bioRxiv · Aug 15, 2022 · PreprintImmunology

Diverse B-cell specific transcriptional contexts of the BCL2 oncogene in mouse models impacts pre-malignant development

L. Zawil, T. Marchiol, B. Brauge, A. Saint-Amand, C. Carrion, E. Dessauge, C. Oblet, S. Le Noir, F. Mourcin, F. Jouan, P. Derouault, M. Alizadeh, M. Brousse, Y. El Makhour, C. Monvoisin, , M. Cogne

The paper investigates how BCL2 oncogene deregulation in mouse models affects B-cell fate and pre-malignant development through two genetic constructs.

bioRxiv · Oct 28, 2021 · PreprintImmunology