J. Pollet

A mouse model of cardiac AL amyloidosis unveils mechanisms of tissue accumulation and toxicity of amyloid fibrils

This paper develops a mouse model of cardiac AL amyloidosis that reproduces human disease features, including amyloid deposits and cardiac dysfunction, and identifies a role for partial LC degradation in fibril formation.

Disruption of immunoglobulin heavy and light chain assembly by antisense oligonucleotides impairs protein homeostasis and myeloma cell survival

This study shows that antisense oligonucleotides targeting IgG mRNA reduce IgG secretion in myeloma cells, leading to toxic free-light chain accumulation and cell death.

RNA-dependent RNA polymerase of predominant human norovirus forms liquid-liquid phase condensates as viral replication factories

Core enhancers of the 3'RR optimize IgH nuclear position and loop conformation for oriented CSR

The paper shows that core enhancers of the IgH 3RR preorganize B cell nuclei to facilitate class switch recombination by controlling nuclear positioning and loop formation.

The impact of vaccine-linked chemotherapy on liver health in a mouse model of chronic Trypanosoma cruzi infection

This study evaluates the impact of vaccine-linked chemotherapy on liver health in a mouse model of chronic Trypanosoma cruzi infection, finding that the treatment better preserves liver health compared to curative doses of benznidazole.

Infection of equine bronchial epithelial cells with a SARS-CoV-2 pseudovirus

This study shows equine bronchial epithelial cells can be infected by a SARS-CoV-2 pseudovirus, but with lower efficiency than human cells, likely due to lower ACE2 expression.

A dual function for the chromatin organizer Special A-T rich Binding Protein 1 in B-lineage cells

This study investigates SATB1's role in B-lineage cells, finding it is not essential for B cell development but acts as both a positive and negative regulator of Ig gene transcription in naive and activated B cells, respectively.

CD95 expression in triple negative breast cancer blocks induction of an inflammatory state through differential regulation of NF-kB Signaling

This study identifies CD95 interaction partners KPC2 and p65, showing CD95 loss in TNBCs promotes NF-κB activation and pro-inflammatory cytokine production.

Genetic Modification to Design a Stable Yeast-expressed Recombinant SARS-CoV-2 Receptor Binding Domain as a COVID-19 Vaccine Candidate

The paper genetically modifies SARS-CoV-2 RBD variants in yeast to identify a more stable and manufacturable vaccine candidate.

SARS-CoV-2 RBD219-N1C1: A Yeast-Expressed SARS-CoV-2 Recombinant Receptor-Binding Domain Candidate Vaccine Stimulates Virus Neutralizing Antibodies and T-cell Immunity in Mice

This study develops a yeast-expressed SARS-CoV-2 RBD protein vaccine candidate, RBD219-N1C1, which induces neutralizing antibodies and T-cell responses in mice.

Splice switching oligonucleotide mediated gene knockdown in B cells and plasma cells

This paper demonstrates the effectiveness of splice switching oligonucleotides in knocking down c-REL and RELA expression in B cells and plasma cells, with potential therapeutic applications in B-lineage cancers.

Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1) Formulated with Aluminum Hydroxide Induces Protective Immunity and Reduces Immune Enhancement

This paper develops a SARS-CoV subunit vaccine using yeast-expressed RBD219-N1 with Alhydrogel® and shows it provides full protection against SARS-CoV challenge in mice.