Author

S. Lier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

D. P. Pandey· 2 shared G. Nesse· 2 shared R. Oellinger· 2 shared A. Anand· 1 shared A. Datta· 1 shared A. K. Mukherjee· 1 shared A. Klungland· 1 shared A. Lang· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersCancer Biology

D. P. Pandey

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4 papers

Recent·Most cited

CDK12/CDK13 inhibition disrupts a transcriptional program critical for glioblastoma survival

S. Lier, S. O. Lund, A. Lipsa, K. B. M. Frauenknecht, I. D. Rein, P. Jain, A. Lang, E. Lang, N. Meyer, A. Datta, S. Anand, G. Nesse, R. J. Forstrom, A. Klungland, J. E. Rinholm, , D. P. Pandey

This study shows that inhibiting CDK12 and CDK13 reduces glioma cell proliferation and migration, and disrupts transcription and cell cycle progression in glioblastoma.

bioRxiv · Jul 14, 2023Cancer Biology

Acinar-to-ductal metaplasia in the pancreas requires a glycolytic switch and functional mitochondria

T. Neuss, N. Wirges, M.-C. Chen, S. Usluer, R. Oellinger, S. Lier, M. Dudek, T. Madl, M. Jastroch, K. Steiger, W. Schmitz, H. Einwaechter, R. M. Schmid

This study identifies a glycolytic switch and functional mitochondria as essential for acinar-to-ductal metaplasia, a key step in pancreatic carcinogenesis.

bioRxiv · Jun 27, 2022 · PreprintCancer Biology

Targeting the ubiquitin-proteasome system in a pancreatic cancer subtype with hyperactive MYC

K. Lankes, Z. Hassan, M. J. Doffo, C. Schneeweis, S. Lier, R. Oellinger, R. Rad, O. H. Kraemer, U. Keller, D. Saur, M. Reichert, G. Schneider, M. Wirth

The paper identifies bortezomib as a potential therapy for MYC hyperactive pancreatic cancer by showing its sensitivity to proteasome inhibition.

bioRxiv · Jul 1, 2020Cancer Biology

Human Telomerase Expression is under Direct Transcriptional Control of the Telomere-binding-factor TRF2

S. Sharma, A. K. Mukherjee, S. S. Roy, S. Bagri, S. Lier, M. Verma, A. Sengupta, M. Kumar, G. Nesse, D. P. Pandey, S. Chowdhury

This study shows TRF2 directly represses hTERT through G-quadruplex-dependent mechanisms, linking telomere regulation to telomerase activity in normal and cancer cells.

bioRxiv · Jan 15, 2020 · PreprintCancer Biology