Author

S. M. Brierley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:electrophysiology· 2 Assay:proteomics· 2 Assay:behavioral assay· 1

Frequent Co-Authors

D. Julius· 2 shared J. Castro· 2 shared K. K. Touhara· 2 shared M. Brizuela· 2 shared N. D. Rossen· 2 shared A. Hendry· 1 shared A. M. Harrington· 1 shared A. Venkataramen· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPhysiology

D. Julius

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Crypt and Villus Enterochromaffin Cells are Distinct Stress Sensors in the Gut

K. K. Touhara, N. D. Rossen, F. Deng, T. Chu, A. M. Harrington, S. Garcia Caraballo, M. Brizuela, T. O'Donnell, O. Cil, S. M. Brierley, Y. Li, D. Julius

This study identifies distinct roles for crypt and villus enterochromaffin cells in sensing gut irritants and oxidative stress through different TRP channels and signaling mechanisms.

bioRxiv · Feb 6, 2024Physiology

The voltage-gated sodium channel NaV1.7 underlies endometriosis-associated chronic pelvic pain

J. Castro, J. Maddern, C. Y. Chow, P. Tran, I. Vetter, G. F. King, S. M. Brierley

This study shows that inhibiting NaV1.7 reduces endometriosis-associated chronic pelvic pain without affecting normal sensation.

bioRxiv · Oct 6, 2022Cell Biology

Gut Enterochromaffin Cells are Critical Drivers of Visceral Pain and Anxiety

J. R. Bayrer, J. Castro, A. Venkataramen, K. K. Touhara, N. D. Rossen, R. D. Morrie, A. Hendry, J. Madden, K. Braverman, G. Schober, M. Brizuela, C. Bueno Silva, H. A. Ingraham, S. M. Brierley, D. Julius

This study shows that enterochromaffin cells drive visceral pain and anxiety through serotonin signaling, with sex differences in baseline sensitivity.

bioRxiv · Apr 4, 2022 · PreprintPhysiology

Orai1- and Orai2-, but not Orai3-mediated ICRAC is regulated by intracellular pH

G. Rychkov, F. H. Zhou, M. K. Adams, S. M. Brierley, L. Ma, G. J. Barritt

This study compares how intracellular pH regulates ICRAC currents mediated by Orai1, Orai2, and Orai3 channels in HEK293T cells.

bioRxiv · Nov 1, 2020Physiology