C. Koch

The ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria

The paper identifies ER-mitochondria contact sites as essential for the ER-SURF pathway's role in transferring mitochondrial precursor proteins from the ER to mitochondria.

Highly multiplexed detection of microRNAs, proteins and small molecules using barcoded molecular probes and nanopore sequencing

This paper develops a rapid, low-cost method for detecting multiple blood biomarkers using barcoded molecular probes and nanopore sequencing, demonstrating detection from human serum without extraction or amplification.

CARPOOL: A library-based platform to rapidly identify next generation chimeric antigen receptors

The paper develops a library-based platform to identify optimized chimeric antigen receptors (CARs) with improved anti-tumor functions through high-throughput screening of diverse signaling domains.

Memory CD8+ T cells mediate early pathogen-specific protection through localized delivery of chemokines and IFNγ to clusters of inflammatory monocytes

This study shows memory CD8+ T cells use cognate antigen to rapidly produce chemokines and IFNγ in splenic monocyte clusters, providing early pathogen protection before clonal expansion.

Strongyle-resistant sheep express their potential across environments and leave limited scope for parasite plasticity

The paper breeds sheep resistant to parasites and finds that resistance remains stable across environments but is affected by specific parasite infections.

Vimentin is Required for Tumor Progression and Metastasis in a Mouse Model of Non-Small Cell Lung Cancer

This study shows that vimentin is essential for metastasis in a mouse model of non-small cell lung cancer, as its loss impairs epithelial-to-mesenchymal transition and oxidative stress response.

Evolution of regulatory networks associated with traits under selection in cichlids

The paper reconstructs gene regulatory networks in cichlids to study GRN evolution linked to adaptive traits, identifying regulatory variants and network rewiring in visual opsin genes.

Lupin (Lupinus sp.) seeds exert anthelmintic activity associated with their alkaloid content

This study shows lupin seeds inhibit parasitic nematodes through alkaloids, offering a potential alternative to combat drug-resistant parasites in ruminants.

Differential physiological role of BIN1 isoforms in skeletal muscle development, function and regeneration

This study investigates the differential roles of BIN1 isoforms in skeletal muscle development, function, and regeneration using knockout mice, finding that ubiquitous BIN1 is essential for development while muscle-specific isoforms are critical for regeneration.