Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody
J. E. Pinto Torres, M. Claes, R. Hendrickx, M. Yuan, N. Smiejkowska, P. Van Wielendaele, A. Hacisuleyman, H. De Winter, S. Muyldermans, P. A. M. Michels, M. D. Walkinshaw, W. Versees, G. Caljon, S. Magez, Y. G.- J. Sterckx
This study identifies a camelid single-domain antibody that allosterically inhibits trypanosomatid pyruvate kinases, reducing parasite growth.
bioRxiv · Jun 14, 2024Biochemistry