K. H. Kim

Mosaic display of stable hemagglutinin monomers induces broad immune responses

This study develops a nanoparticle vaccine displaying conserved influenza HA epitopes, inducing broad neutralizing antibodies against multiple viral subtypes.

Vaginal lactobacilli produce anti-inflammatory beta-carboline compounds.

This study identifies beta-carboline compounds produced by vaginal lactobacilli that reduce inflammation by suppressing immune signaling pathways and demonstrate therapeutic potential in a mouse model.

Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology

This paper introduces OT-TP-LSM for 3D pathology, achieving high imaging depths and enabling virtual H&E image generation via deep learning.

FAM210A mediates an inter-organelle crosstalk essential for protein synthesis and muscle growth in mouse

This study identifies FAM210A as a mediator of mitochondrial-ribosome crosstalk that supports protein synthesis and muscle growth in mice.

Lipid Bilayer Strengthens the Cooperative Network of Membrane Proteins

This study shows that lipid bilayers enhance membrane protein stability and their response to external stimuli by influencing hydrophobic thickness and amphiphile packing.

Vitamin B2 enables peroxisome proliferator-activated receptor α regulation of fasting glucose availability

This study shows that vitamin B2 deficiency impairs PPAR regulation of fasting glucose, and PPAR agonists can rescue this defect.

Mosaic receptor-binding domain nanoparticles induce protective immunity against SARS-CoV-2 challenges

This paper develops a mosaic nanoparticle vaccine, 6RBD-np, that induces full protection against SARS-CoV-2 wild type and Delta variants in mice.

Accumulation of auranofin in white adipose tissues lowers leptin levels and exerts anti-diabetic effects

The paper identifies auranofin as a drug that lowers leptin levels in white adipose tissue and improves insulin sensitivity in obese mice, with anti-diabetic effects.

Generation of tonsil organoids as an ex vivo model for SARS-CoV-2 infection

This study established tonsil epithelial cell-derived organoids and demonstrated their feasibility as an ex vivo model for SARS-CoV-2 infection.

Long-term high-yield skeletal muscle stem cell expansion through staged perturbation of cytokine signaling in a soft hydrogel culture platform

This paper develops a method to expand skeletal muscle stem cells long-term using a hydrogel substrate, cytokine cocktail, and staged p38/{beta} inhibition, achieving high yields of functional Pax7+ cells.

STAT1 dissociates adipose tissue inflammation from insulin sensitivity in obesity

The paper investigates how STAT1 activity in adipocytes affects insulin sensitivity in obesity, finding that STAT1 deletion improves mitochondrial function but does not resolve insulin resistance.

6-O-galloylsalidroside, an active ingredient from Acer tegmentosum, ameliorates alcoholic steatosis and liver injury in a mouse model of chronic ethanol consumption

This study investigates the effect of 6-O-galloylsalidroside on alcoholic steatosis and liver injury in mice, finding it reduces lipid accumulation and liver damage.

Assortment of Stauntonia hexaphylla and Cornus officinalis protect against testosterone-induced benign prostatic hyperplasia through anti-inflammatory and anti-proliferative activity

This study shows that SC extract from Stauntonia hexaphylla and Cornus officinalis reduces prostate size and inflammation in a testosterone-induced BPH model.

An anti-Gn glycoprotein antibody from a convalescent patient potently inhibits the infection of severe fever with thrombocytopenia syndrome virus

This paper isolates an antibody from a recovered SFTS patient that inhibits multiple SFTSV strains and protects mice from infection, suggesting its potential as a therapeutic agent.

Visualization of ligand-induced transmembrane signalling in the full-length human insulin receptor

The paper visualizes how insulin binding changes the structure of the human insulin receptor, leading to autophosphorylation.