S. Mathew

Injury Severity is a Key Contributor to Coagulation Dysregulation and Fibrinogen Consumption

This study quantifies coagulation changes after traumatic injury and links them to injury severity and mortality.

Adaptations to water stress and pastoralism in the Turkana of northwest Kenya

The paper identifies genetic regions associated with adaptation to water stress and pastoralism in the Turkana people using genome sequencing.

SPTLC1 variants associated with childhood onset amyotrophic lateral sclerosis produce distinct sphingolipid signatures through impaired interaction with ORMDL proteins

The paper shows that SPTLC1 variants causing childhood ALS disrupt ORMDL interactions, leading to altered sphingolipid synthesis and distinct lipid signatures, modifiable by L-serine availability.

Reward quantity discrimination in an associative learning task in wild zebrafish (Danio rerio)

This study tests reward quantity discrimination in wild zebrafish using an operant conditioning task and finds some fish can discriminate between stimuli associated with different rewards.

Histone deacetylase 9 promoter hypomethylation associated with adipocyte dysfunction is a statin-related metabolic effect

This study identifies statin-induced hypomethylation of the HDAC9 promoter and its link to adipocyte dysfunction and insulin resistance in T2D risk.

Deletion of beta-fructofuranosidase (invertase) genes is associated with sucrose content in Date Palm fruit

The paper identifies a deletion of two beta-fructofuranosidase genes in high-sucrose date palm cultivars and links it to sucrose content in dried fruit.