Author

P. Froguel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Physiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Organism:mouse· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2

Frequent Co-Authors

A. Bonnefond· 4 shared F. Oger· 3 shared G. A. Rutter· 3 shared J.-S. Annicotte· 3 shared L. Rolland· 3 shared R. Boutry· 3 shared X. Gromada· 3 shared A. Khamis· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersCell Biology

A. Bonnefond

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Author profile →

7 papers

Recent·Most cited

Multiple genetic variants at the SLC30A8 locus affect local super-enhancer activity and influence pancreatic β cell survival and function

M. Hu, I. Kim, I. Moran, W. Peng, O. Sun, A. Bonnefond, A. Khamnis, S. Bonas-Guarch, P. Froguel, G. A. Rutter

The paper identifies multiple genetic variants at the SLC30A8 locus that influence enhancer activity and β cell function, with some variants affecting gene expression and insulin secretion.

bioRxiv · Jul 13, 2023 · PreprintCell Biology

Control of human pancreatic beta cell kinome by GLP-1R biased agonism

J. Xiao, L. Eleid, T. Buenaventura, R. Boutry, A. Bonnefond, B. Jones, G. A. Rutter, P. Froguel, A. Tomas

This study compares kinase activity profiles in human pancreatic beta cells stimulated by GLP-1R agonists with different bias, revealing distinct kinomic responses and potential therapeutic targets.

bioRxiv · Feb 25, 2023Cell Biology

High-throughput quantitative screening of glucose-stimulated insulin secretion and insulin content using automated MAL-DI-TOF mass spectrometry

C. P. Delannoy, E. Heuson, A. Herledan, F. Oger, B. Thiroux, M. Chevalier, X. Gromada, L. Rolland, P. Froguel, B. Deprez, S. Paul, J.-S. Annicotte

This study develops an automated MALDI-TOF mass spectrometry method for high-throughput screening of glucose-stimulated insulin secretion and insulin content in a 384-well plate format using Min6 cells.

bioRxiv · Feb 14, 2023Physiology

A crosstalk between E2F1 and GLP-1 signaling pathways modulates insulin secretion

C. Bourouh, E. Courty, G. Pasquetti, X. Gromada, N. Rabhi, C. Carney, M. Moreno, R. Boutry, L. Rolland, E. Caron, Z. Benfodda, P. Meffre, J. Kerr-Conte, F. Pattou, P. Froguel, , J.-S. Annicotte

This study shows that E2F1 and GLP-1 signaling pathways interact to regulate insulin secretion and glucose homeostasis in beta cells.

bioRxiv · Apr 16, 2021Physiology

Pancreatic β-cell specific loss of E2f1 impairs insulin secretion and β-cell identity through the epigenetic repression of non β-cell programs

F. Oger, C. Bourouh, X. Gromada, M. Moreno, C. Carney, E. Courty, N. Rabhi, E. Durand, S. Amanzougarene, L. Berberian, M. Derhourhi, L. Rolland, S. A. Hannou, P.-D. Denechaud, Z. Benfodda, , J.-S. ANNICOTTE

bioRxiv · Oct 14, 2020Physiology

Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a new regulator of insulin secretion

M. Hu, I. Cebola, G. Carrat, S. Jiang, S. Nawaz, A. Khamis, M. Canouil, P. Froguel, A. Schulte, M. Solimena, M. Ibberson, P. Marchetti, F. L. Cardenas-Diaz, P. Gadue, B. HASTOY, , G. A. Rutter

The paper identifies FCHSD2 as a new regulator of insulin secretion by analyzing 3D chromatin interactions at the STARD10 locus in human islets.

bioRxiv · Mar 31, 2020Cell Biology

Histone deacetylase 9 promoter hypomethylation associated with adipocyte dysfunction is a statin-related metabolic effect

A. Khamis, R. Boutry, M. Canouil, S. Mathew, S. Lobbens, H. Crouch, T. Andrew, A. Abderrahmani, F. Tamanini, P. Froguel

This study identifies statin-induced hypomethylation of the HDAC9 promoter and its link to adipocyte dysfunction and insulin resistance in T2D risk.

bioRxiv · Nov 23, 2019Cell Biology