Author

S. Miyoshi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Physiology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Assay:metagenomics· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

E. B. Chang· 5 shared J. Miyoshi· 5 shared V. Leone· 3 shared C. Cham· 2 shared D. A. Antonopoulos· 2 shared K. Frazier· 2 shared K. Yang· 2 shared O. DeLeon· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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5 shared papersMicrobiology

E. B. Chang

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5 papers

Recent·Most cited

Imbalanced gut microbiota predicts and drives the progression of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in a fast-food diet mouse model

N. Fei, S. Miyoshi, J. B. Hermanson, J. Miyoshi, B. Xie, O. DeLeon, M. Hawkins, W. Charlton, M. D'Souza, J. Hart, D. Sulakhe, K. B. Martinez-Guryn, E. B. Chang, M. R. Charlton, V. A. Leone

The paper shows fast-food diets cause gut microbiota imbalances that predict and drive NAFLD progression in mice, with effects seen in conventionally-raised but not germ-free mice.

bioRxiv · Jan 9, 2023 · PreprintPhysiology

Gut Microbes and the Liver Circadian Clock Partition Glucose and Lipid Metabolism

K. Frazier, S. Manzoor, K. Carroll, O. DeLeon, S. Miyoshi, J. Miyoshi, M. St George, A. Tan, M. Izumo, J. S. Takahashi, M. C. Rao, V. A. Leone, E. B. Chang

This study shows the liver circadian clock and gut microbes interact to regulate glucose and lipid metabolism in mice, with the liver clock driving rhythmic gene expression and gut microbes providing secondary cues when the liver clock is dysfunctional.

bioRxiv · May 24, 2022 · PreprintPhysiology

Early-life microbial intervention reduces colitis risk promoted by antibiotic-induced gut dysbiosis

J. Miyoshi, S. Miyoshi, T. O. Delmont, C. Cham, S. T. M. Lee, A. Sakatani, K. Yang, Y. Shan, E. Kiefl, M. Yousef, S. Crosson, M. Sogin, D. A. Antonopoulos, A. M. Eren, V. Leone, E. B. Chang

The paper shows that adding a specific Bacteroides strain early in life reduces colitis risk in genetically susceptible mice with antibiotic-induced gut dysbiosis.

Gastroenterology · Sep 1, 2021Peer-reviewedMicrobiology

High fat diet disrupts diurnal interactions between REG3g and small intestinal gut microbes resulting in metabolic dysfunction

K. Frazier, A. Kambal, E. A. Zale, J. F. Pierre, N. Hubert, S. Miyoshi, J. Miyoshi, D. Ringus, D. Harris, K. Yang, C. Cham, M. W. Musch, E. B. Chang, V. Leone

bioRxiv · Jun 17, 2020 · PreprintMicrobiology

Metagenomic alterations in gut microbiota precede and predict onset of colitis in the IL10 gene-deficient murine model

J. Miyoshi, S. T. M. Lee, M. Kennedy, M. Puertolas, M. Frith, J. C. Koval, S. Miyoshi, D. A. Antonopoulos, V. Leone, E. B. Chang

The paper examines gut microbiota metagenomic profiles in a murine model to predict colitis onset and finds functional subsystems, particularly nitrogen metabolism, differ between mice that develop colitis and those that do not.

bioRxiv · May 4, 2020Microbiology