Author

S. Mohandas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 9 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 11 Research Focus:host-pathogen & immune response· 11 Organism:mouse· 9 Organism:rat· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

P. Abraham· 8 shared A. Kumar· 6 shared P. Sarkale· 6 shared P. Yadav· 6 shared A. Shete· 5 shared G. Sapkal· 5 shared N. Gupta· 5 shared P. D. Yadav· 5 shared

Activity by Year

2020-2022 · peak 7/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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8 shared papersMicrobiology

P. Abraham

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Protective efficacy of COVAXIN(R) against Delta and Omicron variants in hamster model

P. Yadav, S. Mohandas, A. Shete, G. Sapkal, G. Deshpande, A. Kumar, K. Wakchaure, H. Dighe, R. Jain, B. Ganneru, J. Yemul, P. Gawande, K. M. Vadrevu, P. Abraham

This study evaluates COVAXIN's protective efficacy against Delta and Omicron variants in hamsters, showing improved protection with a third dose and reduced disease severity.

bioRxiv · Jun 14, 2022Immunology

Pathogenicity of SARS-CoV-2 Omicron in Syrian hamsters and its neutralization with different Variants of Concern

S. Mohandas, P. D. Yadav, G. Sapkal, A. M. Shete, G. Deshpande, D. A. Nyayanit, D. Y. Patil, M. Kadam, A. Kumar, C. Mote, R. Jain

This study evaluates the pathogenicity of SARS-CoV-2 Omicron BA.1 in Syrian hamsters and finds reduced cross-neutralization against other variants.

bioRxiv · Jan 19, 2022 · PreprintMicrobiology

An in vitro and in vivo approach for the isolation of Omicron variant from human clinical specimens

P. D. Yadav, N. Gupta, V. Potdar, S. Mohandas, R. R. Sahay, P. Sarkale, A. M. Shete, A. Razdan, D. Y. Patil, D. A. Nyayanit, Y. Joshi, S. Patil, T. Majumdar, H. Dighe, B. Malhotra, , P. Abraham

The paper isolates the Omicron variant from Syrian hamsters and compares its genetic changes to human clinical specimens and Vero CCL-81 cell passages.

bioRxiv · Jan 2, 2022 · PreprintMicrobiology

ZRC3308 monoclonal antibody cocktail shows protective efficacy in Syrian hamsters against SARS-CoV-2 infection

P. Yadav, S. K. Mendiratta, S. Mohandas, A. K. Singh, P. Abraham, A. Shete, S. Bandhyopadhyay, S. Kumar, A. Parikh, P. Kalita, V. Sharma, H. Pandya, C. G. Patel, M. Patel, S. Soni, , M. Jain

The paper develops a monoclonal antibody cocktail (ZRC-3308) effective against multiple SARS-CoV-2 variants in Syrian hamsters.

bioRxiv · Sep 16, 2021Microbiology

Isolation of SARS-CoV-2 B.1.1.28.2 P2 variant and pathogenicity comparison with D614G variant in hamster model

P. Yadav, S. Mohandas, P. Sarkale, D. Nyayanit, A. Shete, R. Sahay, V. Potdar, S. Baradkar, N. Gupta, G. Sapkal, P. Abraham, S. Panda, B. Bhargava

The paper isolates the SARS-CoV-2 B.1.1.28.2 (P.2) variant from travelers and compares its pathogenicity to the D614G variant in hamsters, finding it more severe and with reduced neutralization.

bioRxiv · May 24, 2021Microbiology

SARS CoV-2 variant B.1.617.1 is highly pathogenic in hamsters than B.1 variant

P. D. Yadav, S. Mohandas, A. M. Shete, D. A. Nyayanit, N. Gupta, D. Y. Patil, G. N. Sapkal, V. Potdar, M. Kadam, A. kumar, S. Kumar, D. Suryavanshi, C. S. Mote, P. Abraham, S. Panda, B. Bhargava

This study compares the pathogenicity of SARS-CoV-2 variants B.1 and B.1.617.1 in hamsters, finding B.1.617.1 causes greater body weight loss, higher viral load, and more severe lung lesions.

bioRxiv · May 5, 2021 · PreprintMicrobiology

Possible role of accessory proteins in the viral replication for the 20I/501Y.V1 (B.1.1.7) SARS-CoV-2 variant

D. A. Nyayanit, P. Sarkale, A. Shete-Aich, A. Kumar, S. Patil, T. Majumdar, S. Baradkar, P. Gawande, S. Mohandas, P. D. Yadav

The paper examines the replication cycle and transcriptional patterns of the B.1.1.7 SARS-CoV-2 variant, finding higher expression of ORF6 and ORF8 and increased infectivity despite lower copy numbers.

bioRxiv · Apr 30, 2021Microbiology

Comparison of SARS-CoV-2 VOC 202012/01 (UK variant) and D614G variant transmission by different routes in Syrian hamsters

S. Mohandas, P. Yadav, D. Nyayanit, A. Shete-Aich, P. Sarkale, S. Hundekar, S. Kumar, K. Lole

This study compares the transmission efficiency of SARS-CoV-2 UK variant and D614G variant in Syrian hamsters via different routes, finding comparable transmission between the two variants.

bioRxiv · Mar 26, 2021Microbiology

Comparison of the pathogenicity and virus shedding of SARS CoV-2 VOC 202012/01 and D614G variant in hamster model

S. Mohandas, P. D. Yadav, D. Nyayanit, G. Deshpande, A. S. Aich, G. Sapkal, S. Kumar, R. Jain, M. Kadam, A. Kumar, D. Y. Patil, P. Sarkale, P. Gawande, P. Abraham

This study compares the pathogenicity and virus shedding of SARS-CoV-2 VOC 202012/01 and D614G variants in hamsters, finding higher viral shedding and mild lung pathology with VOC 202012/01.

bioRxiv · Feb 25, 2021 · PreprintMicrobiology

Assessment of immunogenicity and protective efficacy of ZyCoV-D DNA vaccine candidates in Rhesus macaques against SARS-CoV-2 infection

P. Yadav, S. Kumar, K. Agarwal, M. Jain, D. Patil, K. Maithal, B. Mathapati, S. Giri, S. Mohandas, A. Shete, G. Sapkal, D. Patil, A. Dey, H. Chandra, G. Deshpande, , P. Abraham

This study evaluates two doses of ZyCoV-D DNA vaccine in rhesus macaques, finding that the 2mg dose via Needle Free Injection System provides better immune response and protection against SARS-CoV-2.

bioRxiv · Feb 2, 2021 · PreprintMicrobiology

Evaluation of Safety and Immunogenicity of an Adjuvanted, TH-1 Skewed, Whole Virion Inactivated SARS-CoV-2 Vaccine - BBV152

B. Ganneru, H. Jogdand, V. K. Dharam, N. Reddy, S. D. Prasad, S. Vellimudu, K. M. Ella, R. Ravikrishnan, A. Awasthi, J. Jose, P. Rao, D. Kumar, R. Ella, P. Abraham, P. Yadav, , K. V. Mohan

This study evaluates the safety and immunogenicity of a SARS-CoV-2 vaccine BBV152 in mice, rats, and rabbits, showing high antibody titers and Th1-biased responses with the TLR7/8 agonist adjuvant.

bioRxiv · Sep 9, 2020 · PreprintImmunology