Author

G. Deshpande

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Immunology· 3 Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 11 Research Focus:host-pathogen & immune response· 9 Organism:human· 7 Organism:mouse· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

P. Abraham· 8 shared D. Y. Patil· 7 shared G. Sapkal· 7 shared N. Gupta· 5 shared P. D. Yadav· 5 shared R. R. Sahay· 5 shared A. Kumar· 4 shared A. M. Shete· 4 shared

Activity by Year

2021-2023 · peak 7/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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Curved chords = mutual co-authorship

8 shared papersMicrobiology

P. Abraham

Mutual co-authors in cluster

Author profile →

12 papers

Recent·Most cited

Degradomic identification of membrane type 1-matrix metalloproteinase (MT1-MMP/MMP14) as an ADAMTS9 and ADAMTS20 substrate

S. Nandadasa, D. Martin, G. Deshpande, K. L. Robert, M. S. Stack, Y. Itoh, S. S. APTE

This study identifies ADAMTS9 and ADAMTS20 as substrates of MT1-MMP using N-terminomics, showing their role in regulating MT1-MMP activity and cell-surface function.

Molecular & Cellular Proteomics · Jun 1, 2023Peer-reviewedBiochemistry

Myeloid-cell-specific role of Gasdermin D in promoting lung cancer progression in mice.

c. Traughber, G. deshpande, k. neupane, M. Khan, M. R. McMullen, S. Swaidani, E. Opoku, S. Muppals, J. Smith, L. Nagy, K. Gulshan

This study shows that GsdmD in myeloid cells promotes lung cancer metastasis in mice by enhancing inflammasome activity and IL-1β release.

bioRxiv · Aug 22, 2022Cancer Biology

Protective efficacy of COVAXIN(R) against Delta and Omicron variants in hamster model

P. Yadav, S. Mohandas, A. Shete, G. Sapkal, G. Deshpande, A. Kumar, K. Wakchaure, H. Dighe, R. Jain, B. Ganneru, J. Yemul, P. Gawande, K. M. Vadrevu, P. Abraham

This study evaluates COVAXIN's protective efficacy against Delta and Omicron variants in hamsters, showing improved protection with a third dose and reduced disease severity.

bioRxiv · Jun 14, 2022Immunology

Substantial immune response in Omicron infected breakthrough and unvaccinated individuals against SARS-CoV-2 variants of concerns

P. D. Yadav, G. Sapkal, R. R. Sahay, V. Potdar, G. Deshpande, D. Y. Patil, D. A. Nyayanit, A. M. Shete, J. Shastri, P. Awate, B. Malhotra, P. Abraham

This study compares IgG and neutralizing antibody responses in vaccinated and unvaccinated individuals infected with the Omicron variant of SARS-CoV-2, showing reduced neutralization against Omicron compared to earlier variants.

bioRxiv · Jan 24, 2022Microbiology

Pathogenicity of SARS-CoV-2 Omicron in Syrian hamsters and its neutralization with different Variants of Concern

S. Mohandas, P. D. Yadav, G. Sapkal, A. M. Shete, G. Deshpande, D. A. Nyayanit, D. Y. Patil, M. Kadam, A. Kumar, C. Mote, R. Jain

This study evaluates the pathogenicity of SARS-CoV-2 Omicron BA.1 in Syrian hamsters and finds reduced cross-neutralization against other variants.

bioRxiv · Jan 19, 2022 · PreprintMicrobiology

Horizontal mitochondrial transfer from the microenvironment increases glioblastoma tumorigenicity

D. C. Watson, D. Bayik, S. E. Williford, A. Lauko, Y. Zhou, G. Deshpande, J. Seder, J. A. Mears, F. Cheng, A. B. Hjelmeland, J. D. Lathia

The paper identifies horizontal mitochondrial transfer from astrocytes to glioblastoma cells as a mechanism that enhances tumorigenicity by improving mitochondrial function and metabolic capacity.

bioRxiv · Sep 1, 2021Cancer Biology

Neutralization of Delta variant with sera of Covishield vaccinees and COVID-19 recovered vaccinated individuals

G. Sapkal, P. D. Yadav, R. R. Sahay, G. Deshpande, N. Gupta, D. A. Nyayanit, D. Y. Patil, S. Kumar, P. Abraham, S. Panda, B. Bhargava

This study evaluates immune response in Covishield vaccinated and recovered individuals against the Delta variant, finding higher protection in breakthrough cases and recovered individuals compared to single or double vaccinated groups.

bioRxiv · Jul 1, 2021Microbiology

Neutralization against B.1.351 and B.1.617.2 with sera of COVID-19 recovered cases and vaccinees of BBV152

P. D. Yadav, G. Sapkal, R. Ella, R. R. Sahay, D. A. Nyayanit, D. Y. Patil, G. Deshpande, A. M. Shete, N. Gupta, V. K. Mohan, P. Abraham, S. Panda, B. Bhargava

This study assesses the neutralization efficacy of sera from COVID-19 recovered cases and BBV152 vaccinees against SARS-CoV-2 variants B.1.351 and B.1.617.2, showing reduced titers but still protective responses.

bioRxiv · Jun 5, 2021 · PreprintMicrobiology

Neutralization potential of Covishield vaccinated individuals sera against B.1.617.1

P. Yadav, G. N. Sapkal, P. Abraham, G. Deshpande, D. Nyayanit, D. Y. Patil, N. Gupta, R. R. Sahay, A. Shete, S. Kumar, S. Panda, B. Bhargava

This study compares neutralizing antibody responses in Covishield-vaccinated individuals and COVID-19 recovered subjects against B.1 and B.1.617.1 variants, finding higher neutralization in recovered subjects.

bioRxiv · May 12, 2021Immunology

Neutralization of variant under investigation B.1.617 with sera of BBV152 vaccinees

P. Yadav, G. N. Sapkal, P. Abraham, R. Ella, G. Deshpande, D. Y. Patil, D. Nyayanit, N. Gupta, R. R. Sahay, A. M. Shete, S. Panda, B. Bhargava, V. K. Mohan

The paper assesses the neutralizing ability of sera from BBV152 vaccinees and convalescent COVID-19 patients against B.1.617 variants.

bioRxiv · Apr 23, 2021Immunology

Comparison of the pathogenicity and virus shedding of SARS CoV-2 VOC 202012/01 and D614G variant in hamster model

S. Mohandas, P. D. Yadav, D. Nyayanit, G. Deshpande, A. S. Aich, G. Sapkal, S. Kumar, R. Jain, M. Kadam, A. Kumar, D. Y. Patil, P. Sarkale, P. Gawande, P. Abraham

This study compares the pathogenicity and virus shedding of SARS-CoV-2 VOC 202012/01 and D614G variants in hamsters, finding higher viral shedding and mild lung pathology with VOC 202012/01.

bioRxiv · Feb 25, 2021 · PreprintMicrobiology

Assessment of immunogenicity and protective efficacy of ZyCoV-D DNA vaccine candidates in Rhesus macaques against SARS-CoV-2 infection

P. Yadav, S. Kumar, K. Agarwal, M. Jain, D. Patil, K. Maithal, B. Mathapati, S. Giri, S. Mohandas, A. Shete, G. Sapkal, D. Patil, A. Dey, H. Chandra, G. Deshpande, , P. Abraham

This study evaluates two doses of ZyCoV-D DNA vaccine in rhesus macaques, finding that the 2mg dose via Needle Free Injection System provides better immune response and protection against SARS-CoV-2.

bioRxiv · Feb 2, 2021 · PreprintMicrobiology