A. Awasthi

Non-canonical NF-κB signaling promotes intestinal inflammation by restraining the tolerogenic β-catenin-Raldh2 axis in dendritic cells

Video Diffusion models for the apoptosis forcasting

This paper introduces a video diffusion model for early apoptosis prediction by considering cell-cell interactions and spatial-temporal dynamics, achieving high accuracy and low error rates.

VapC12 ribonuclease toxin modulates host immune response during Mycobacterium tuberculosis infection

This study shows that the VapC12 toxin in Mycobacterium tuberculosis modulates host immune responses, promoting pathogen survival by altering T-cell and neutrophil responses.

Prophylactic treatment of Glycyrrhiza glabra mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosis.

This study shows that Glycyrrhiza glabra extract reduces inflammation and lung damage in hamsters infected with SARS-CoV-2 by lowering pro-inflammatory cytokines and NETosis.

SARS-CoV-2 and its variants, but not Omicron, induces thymic atrophy and impaired T cell development

This study shows SARS-CoV-2 and its variants cause thymic atrophy and impair T cell development, with Omicron having a lesser effect than Delta.

Proinflammatory innate cytokines and metabolomic signatures shape the T cell response in active COVID-19

The paper examines how proinflammatory cytokines and metabolomic signatures influence T cell responses in active COVID-19 patients, showing preserved T cell responses against variants despite reduced antibody responses.

A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 delta variant

This paper identifies two potent monoclonal antibodies from an Indian donor that neutralize SARS-CoV-2 variants including Delta, showing protection in a mouse model.

Effect of prophylactic use of intra-nasal oil formulations in the hamster model of Covid-19

The paper evaluates two intra-nasal oil formulations in a hamster model of SARS-CoV-2 infection, finding that Anu oil reduces viral load, body weight loss, and lung pathology compared to the control.

Immunological and cardio-vascular pathologies associated with SARS-CoV-2 infection in golden syrian hamster

This study shows that SARS-CoV-2 infection in golden Syrian hamsters causes lung and cardiovascular pathologies similar to human COVID-19, suggesting GSH as a model for studying long-term effects.

Evaluation of Safety and Immunogenicity of an Adjuvanted, TH-1 Skewed, Whole Virion Inactivated SARS-CoV-2 Vaccine - BBV152

This study evaluates the safety and immunogenicity of a SARS-CoV-2 vaccine BBV152 in mice, rats, and rabbits, showing high antibody titers and Th1-biased responses with the TLR7/8 agonist adjuvant.