S. P. Brown

The impact of phage and phage resistance on microbial community dynamics

This study examines how phage and phage resistance mechanisms influence microbial community dynamics through a controlled experiment with an artificial bacterial community.

The las and rhl Quorum Sensing Systems in Pseudomonas aeruginosa Form a Multi-Signal Reciprocal Network Which Can Tune Reactivity to Variations in Physical and Social Environments

The paper shows that the las and rhl quorum sensing systems in Pseudomonas aeruginosa interact reciprocally and cooperatively, enhancing their responsiveness to environmental changes.

Modular gene interactions drive modular pan-genome evolution in bacteria.

The paper develops an evolutionary model showing that gene interactions drive modular pan-genome evolution in bacteria, with co-segregation networks reflecting gene regulatory and metabolic interactions.

The dynamic response of quorum-sensing to density is robust to signal supplementation and signal synthase knockouts

This study investigates how quorum-sensing (QS) in Pseudomonas aeruginosa responds to genetic and signal perturbations, showing robustness in density-dependent gene expression despite signal supplementation or synthase knockouts.

Machine learning identification of Pseudomonas aeruginosa strains from colony image data

This paper uses deep learning to classify Pseudomonas aeruginosa strains based on colony morphology, achieving high accuracy despite limited data.

Eudicot primary cell wall glucomannan is related in synthesis, structure and function to xyloglucan

The paper shows that β-galactoglucomannan (β-GGM) in eudicot primary cell walls is structurally and functionally similar to xyloglucan (XyG).

Bacterial quorum sensing allows graded and bimodal cellular responses to variations in population density

This study shows Pseudomonas aeruginosa uses quorum sensing to produce graded and bimodal responses to population density changes, without a clear threshold for gene expression activation.

Antibiotics drive expansion of rare pathogens in a chronic infection microbiome model

The paper develops a synthetic infection microbiome model to show antibiotics can drive expansion of rare pathogens through competitive release in chronic infections.

Building reusable phage and antibiotic treatments via exploitation of bacteria-phage coevolutionary dynamics.

This study shows that combining phage with antibiotics can enable effective reuse of treatments by altering co-evolutionary dynamics in Pseudomonas aeruginosa.

Pseudomonas aeruginosa reaches collective decisions via transient segregation of quorum sensing activities across cells

This study shows Pseudomonas aeruginosa cells transiently segregate into low and high receptor expressers to regulate quorum sensing, providing a bet-hedging strategy.

Combinatorial quorum sensing in Pseudomonas aeruginosa allows for novel cheating strategies

This study shows Pseudomonas aeruginosa can evolve cheating strategies by rewiring its quorum sensing response, bypassing metabolic incentives to cooperate and gaining a competitive fitness advantage.

Allelic polymorphism shapes community function in evolving Pseudomonas aeruginosa populations

This study shows that allelic polymorphism in Pseudomonas aeruginosa affects community function and antibiotic tolerance during evolution in biofilms.

Community lifespan, niche expansion and the evolution of interspecific cooperation

This study investigates how niche expansion facilitates the evolution of mutualism by enhancing resource sharing, especially in high-density populations, and shows its role in promoting reproductive restraint and vulnerability to cheaters.

In silico bacteria evolve robust cooperation via complex quorum-sensing strategies

The paper uses agent-based simulations to study how environmental factors shape the evolution of quorum-sensing strategies in bacteria, revealing how genetic constraints influence cooperation and resilience against cheaters.

Individual- versus group-optimality in the production of secreted bacterial compounds

The paper shows that for shared compounds with saturating benefits, division of labor evolves when production costs diminish with higher output, as demonstrated through mathematical modeling and experimental testing with pyoverdine.

Modified antibiotic adjuvant ratios can slow and steer the evolution of resistance: co-amoxiclav as a case study

This study shows that adjusting the ratio of antibiotic to adjuvant in co-amoxiclav can slow and steer resistance evolution in E. coli.

Division of labor, bet hedging, and the evolution of mixed biofilm investment strategies

This paper investigates why bacterial lineages invest in both fast-growing planktonic and slow-growing biofilm cells, finding that mixed investment is advantageous for environmental resilience.

An oscillating tragedy of the commons in replicatordynamics with game-environment feedback

The paper generalizes evolutionary game theory to show oscillatory tragedy of the commons dynamics where environmental states and strategies coevolve, finding cooperation is necessary to avoid system collapse.