R. Kuemmerli

A new protocol for multispecies bacterial infections in zebrafish and their monitoring through automated image analysis

The paper develops a protocol for multispecies bacterial infections in zebrafish and an automated image analysis pipeline to monitor them.

Siderophore synthetase-receptor gene coevolution reveals habitat- and pathogen-specific bacterial iron interaction networks

The paper develops a co-evolution algorithm to predict bacterial iron interaction networks based on siderophore synthetase-receptor gene pairs across Pseudomonas genomes, revealing habitat- and pathogen-specific interactions.

Space and epigenetic inheritance determine inter-individual differences in siderophore gene expression in bacterial colonies

The paper tracks gene expression of siderophore synthesis genes in Pseudomonas aeruginosa colonies to identify sources and functional roles of cellular heterogeneity.

Antimicrobial activity of iron-depriving pyoverdines against human opportunistic pathogens

This study identifies pyoverdines from Pseudomonas spp. as potent antibacterials against human pathogens by inducing iron starvation, showing reduced resistance potential compared to antibiotics.

Predicting bacterial interaction outcomes from monoculture growth and supernatant assays

The paper predicts competitive rank order in a 4-species bacterial community using monoculture growth and supernatant assay data.

Rapid and strain-specific resistance evolution of Staphylococcus aureus against inhibitory molecules secreted by Pseudomonas aeruginosa

This study shows S. aureus rapidly evolves resistance to P. aeruginosa inhibitory molecules through strain-specific mutations in membrane transporters and virulence trait up-regulation.

Enforced specialization fosters mutual cheating and not division of labour in the bacterium Pseudomonas aeruginosa

This study shows that enforced specialization in Pseudomonas aeruginosa leads to mutual cheating rather than division of labour under iron limitation.

Siderophores drive invasion dynamics in bacterial communities through their dual role as public good versus public bad

The paper shows siderophores can either promote or hinder bacterial invasion depending on their dual role as public good or public bad.

Pseudomonas aeruginosa reaches collective decisions via transient segregation of quorum sensing activities across cells

This study shows Pseudomonas aeruginosa cells transiently segregate into low and high receptor expressers to regulate quorum sensing, providing a bet-hedging strategy.

From heterogeneity to homogeneity: coordination of siderophore gene expression among clonal cells of the bacterium Pseudomonas aeruginosa

The paper uses microscopy to study siderophore gene expression in Pseudomonas aeruginosa, finding initial heterogeneity that becomes homogenized with increasing cell density and a shift in siderophore usage.

Ecology drives the evolution of diverse siderophore-production strategies in the opportunistic human pathogen Pseudomonas aeruginosa

The paper shows that Pseudomonas aeruginosa evolves diverse pyoverdine production strategies in different environments, with hyper-producers favored in high viscosity and iron-rich conditions.

Local adaptation, geographical distance and phylogenetic relatedness: assessing the drivers of siderophore-mediated social interactions in natural bacterial communities

The paper investigates factors driving siderophore-mediated social interactions in Pseudomonas communities, finding phylogenetic relatedness, not geographical distance, primarily determines cooperation and cheating behaviors.

The loss of the pyoverdine secondary receptor in Pseudomonas aeruginosa results in a fitter strain suitable for population invasion

This study shows that deleting the pyoverdine secondary receptor FpvB in Pseudomonas aeruginosa creates a fitter strain that outcompetes wildtype in structured environments under antibiotic stress.

Combining antibiotics with antivirulence compounds can have synergistic effects and reverse selection for antibiotic resistance in Pseudomonas aeruginosa

This study combines antivirulence compounds with antibiotics to treat Pseudomonas aeruginosa infections, finding synergistic effects and reduced resistance selection in some cases.

Antagonistic interactions subdue inter-species green-beard cooperation in bacteria.

The paper shows that inter-species green-beard cooperation in bacteria is undermined by antagonistic interactions, as Pseudomonas aeruginosa outcompetes Burkholderia cenocepacia despite shared cooperative traits.

In vivo microscopy reveals the impact of Pseudomonas aeruginosa social interactions on host colonization

The paper uses in vivo microscopy to study Pseudomonas aeruginosa social interactions in C. elegans, finding that non-producers cannot outcompete producers due to spatial segregation.

Understanding policing as a mechanism of cheater control in cooperating bacteria

The paper uses individual-based modeling to show that toxin-mediated policing can enforce cooperation in bacteria under specific conditions, but its evolutionary stability is limited.

Probing the evolutionary robustness of two repurposed drugs targeting iron uptake in Pseudomonas aeruginosa

This study evaluates the evolutionary robustness of two drugs targeting iron uptake in Pseudomonas aeruginosa, finding that resistance development varies between the drugs.

Environmental determinants of pyoverdine production, exploitation and competition in natural Pseudomonas communities

The paper investigates how environmental factors influence pyoverdine production and competition among Pseudomonas strains in natural communities.