Author

S. Azimi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 7 Organism:human· 4 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

S. P. Diggle· 6 shared J. Vanderwoude· 2 shared S. P. Brown· 2 shared A. E. Roberts· 1 shared A. McNally· 1 shared C. G. Hubert· 1 shared C. Lokh· 1 shared D. A. A. Ala'Aldeen· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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6 shared papersMicrobiology

S. P. Diggle

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The Role of Hypermutation and Collateral Sensitivity in Antimicrobial Resistance Diversity of Pseudomonas aeruginosa Populations in Cystic Fibrosis Lung Infection

J. Vanderwoude, S. Azimi, T. Read, S. P. Diggle

This study examines AMR diversity in Pseudomonas aeruginosa from CF patients, finding that genomic diversity does not consistently correlate with phenotypic AMR diversity and hypermutator strains may show increased antimicrobial sensitivity.

bioRxiv · Jun 14, 2023 · PreprintMicrobiology

How to use transcriptomic data for game-theoretic modeling of treatment-induced resistance in cancer cells? A case study in patient-derived glioblastoma organoids

L. Spekking, C. Lokh, W. Jung, M. Verduin, S. Azimi, C. G. Hubert, M. Vooijs, R. Cavill, K. Stankova

This paper uses transcriptomic data from glioblastoma organoids to predict evolutionary responses to irradiation using game-theoretic models, finding hypoxia drives short-term resistance while supervised methods best estimate evolutionary dynamics.

bioRxiv · Jan 26, 2022 · PreprintCancer Biology

O-specific antigen-dependent surface hydrophobicity mediates aggregate assembly type in Pseudomonas aeruginosa

S. Azimi, J. Thomas, S. Cleland, J. E. Curtis, J. B. Goldberg, S. P. Diggle

This study shows that O-specific antigen affects surface hydrophobicity, leading to different aggregate types in Pseudomonas aeruginosa under CF-like conditions.

bioRxiv · Jan 14, 2021Microbiology

The evolution of virulence in Pseudomonas aeruginosa during chronic wound infection

J. Vanderwoude, D. Fleming, S. Azimi, U. Trivedi, K. P. Rumbaugh, S. P. Diggle

This study examines the evolution of virulence in Pseudomonas aeruginosa during chronic wound infection and finds that virulence evolves differently in various lines and that similar genetic adaptations occur across infection environments.

bioRxiv · May 29, 2020Microbiology

Combinatorial quorum sensing in Pseudomonas aeruginosa allows for novel cheating strategies

J. Gurney, S. Azimi, S. P. Brown, S. P. Diggle

This study shows Pseudomonas aeruginosa can evolve cheating strategies by rewiring its quorum sensing response, bypassing metabolic incentives to cooperate and gaining a competitive fitness advantage.

bioRxiv · Apr 9, 2020Microbiology

Allelic polymorphism shapes community function in evolving Pseudomonas aeruginosa populations

S. Azimi, A. E. Roberts, S. Peng, J. S. Weitz, A. McNally, S. P. Brown, S. P. Diggle

This study shows that allelic polymorphism in Pseudomonas aeruginosa affects community function and antibiotic tolerance during evolution in biofilms.

bioRxiv · Mar 31, 2020Microbiology

A role for Fibroblast Growth Factor Receptor 1 in the pathogenesis of Neisseria meningitidis

S. Azimi, L. M. Wheldon, N. J. Oldfield, D. A. A. Ala'Aldeen, K. Wooldridge

This study demonstrates that Neisseria meningitidis interacts with FGFR1 on human HBMECs, and FGFR1 activation is necessary for bacterial internalization.

bioRxiv · Mar 16, 2018Microbiology

A simple mung bean infection model for studying the virulence of Pseudomonas aeruginosa

S. Garge, S. Azimi, S. P. Diggle

This paper develops a mung bean infection model to study Pseudomonas aeruginosa virulence, showing that QS mutants are less virulent than wild-type PAO1.

bioRxiv · Mar 15, 2018Microbiology