S. P. Diggle

The Role of Hypermutation and Collateral Sensitivity in Antimicrobial Resistance Diversity of Pseudomonas aeruginosa Populations in Cystic Fibrosis Lung Infection

This study examines AMR diversity in Pseudomonas aeruginosa from CF patients, finding that genomic diversity does not consistently correlate with phenotypic AMR diversity and hypermutator strains may show increased antimicrobial sensitivity.

High prevalence of lipopolysaccharide mutants and R2-Pyocin susceptible variants in Pseudomonas aeruginosa populations sourced from cystic fibrosis lung infections

This study examines R2-pyocin susceptibility in Pseudomonas aeruginosa from CF lung infections, finding high prevalence of susceptible variants and no correlation with LPS phenotypes.

Frequency of quorum sensing mutations in Pseudomonas aeruginosa strains isolated from different environments

This study examines the frequency of quorum sensing mutations in Pseudomonas aeruginosa across different environments and finds that lasR mutations are common and not limited to infections, while pqs system proteins show high variability.

O-specific antigen-dependent surface hydrophobicity mediates aggregate assembly type in Pseudomonas aeruginosa

This study shows that O-specific antigen affects surface hydrophobicity, leading to different aggregate types in Pseudomonas aeruginosa under CF-like conditions.

Heterogenous susceptibility to R-pyocin killing in populations of Pseudomonas aeruginosa sourced from cystic fibrosis lungs

The paper examines R-pyocin susceptibility in Pseudomonas aeruginosa populations from CF lungs, finding heterogeneous responses due to LPS core variations.

The evolution of virulence in Pseudomonas aeruginosa during chronic wound infection

This study examines the evolution of virulence in Pseudomonas aeruginosa during chronic wound infection and finds that virulence evolves differently in various lines and that similar genetic adaptations occur across infection environments.

Combinatorial quorum sensing in Pseudomonas aeruginosa allows for novel cheating strategies

This study shows Pseudomonas aeruginosa can evolve cheating strategies by rewiring its quorum sensing response, bypassing metabolic incentives to cooperate and gaining a competitive fitness advantage.

Allelic polymorphism shapes community function in evolving Pseudomonas aeruginosa populations

This study shows that allelic polymorphism in Pseudomonas aeruginosa affects community function and antibiotic tolerance during evolution in biofilms.

Competition in biofilms between cystic fibrosis isolates of Pseudomonas aeruginosa is influenced by R-pyocins

This study investigates the role of R-pyocins in competition between Pseudomonas aeruginosa strains in cystic fibrosis patients, finding they influence biofilm dominance and antimicrobial activity.

A simple mung bean infection model for studying the virulence of Pseudomonas aeruginosa

This paper develops a mung bean infection model to study Pseudomonas aeruginosa virulence, showing that QS mutants are less virulent than wild-type PAO1.

The fitness of Pseudomonas aeruginosa quorum sensing signal cheats is influenced by the diffusivity of the environment

The paper shows that QS signal molecules in Pseudomonas aeruginosa act as social public goods, with their accessibility influenced by environmental diffusivity and population structure.

Environmental modification via a quorum sensing molecule influences the social landscape of siderophore production

This study shows that the quorum sensing molecule PQS in Pseudomonas aeruginosa increases siderophore production, which benefits non-producing cheats and affects social competition.