S. P. Curran

Oolonghomobisflavans from Camellia sinensis disaggregate tau fibrils across Alzheimer's disease models

This study shows that Oolonghomobisflavans reduce tau fibrils and improve health in Alzheimer's models.

C. elegans display antipathy behavior towards food after contemporaneous integration of nutritional needs and dietary lipid availability

This study identifies molecular mechanisms by which C. elegans avoid Methylobacterium after ingestion, integrating lipid metabolism and dietary needs to influence food preference.

Hepatic WDR23 proteostasis mediates insulin clearance by regulating insulin degrading enzyme activity

This study shows that WDR23 proteostasis regulates insulin-degrading enzyme activity in the liver, affecting insulin clearance and metabolic health.

Bacterial diets differentially alter lifespan and healthspan trajectories in C. elegans

This study examines how different bacterial diets affect lifespan and healthspan in C. elegans, identifying specific bacterial strains that alter life history traits and promote longevity.

Loss of flavin adenine dinucleotide (FAD) impairs sperm function and male reproductive advantage in C. elegans.

This study shows that reduced FAD levels due to impaired mitochondrial proline catabolism in C. elegans males leads to sperm dysfunction and reduced reproductive fitness, which can be reversed by restoring FAD levels.