Author

S. P. Niclou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell-cell communication· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

A. Oudin· 4 shared A. Golebiewska· 3 shared A. Lipsa· 3 shared A. Michelucci· 2 shared A. Muller· 2 shared A. Poli· 2 shared A. Skupin· 2 shared B. Klink· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

A. Oudin

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Author profile →

5 papers

Recent·Most cited

T-Cell-Mediated Killing in Glioblastoma Organoids induced by Adenoviral Delivery of the CIITA Transgene

I. Salvato, E. Klein, A. Poli, M. Rezaeipour, L. Ermini, B. Nosirov, A. Lipsa, A. Oudin, V. Baus, G. M. Dore, A. Cosma, A. Golebiewska, A. Marchini, S. P. Niclou

This study shows that adenoviral delivery of CIITA enhances T-cell mediated killing of glioblastoma organoids, with some MHC-II-independent immune responses observed.

bioRxiv · Jan 22, 2024 · PreprintCancer Biology

CDK12/CDK13 inhibition disrupts a transcriptional program critical for glioblastoma survival

S. Lier, S. O. Lund, A. Lipsa, K. B. M. Frauenknecht, I. D. Rein, P. Jain, A. Lang, E. Lang, N. Meyer, A. Datta, S. Anand, G. Nesse, R. J. Forstrom, A. Klungland, J. E. Rinholm, , D. P. Pandey

This study shows that inhibiting CDK12 and CDK13 reduces glioma cell proliferation and migration, and disrupts transcription and cell cycle progression in glioblastoma.

bioRxiv · Jul 14, 2023Cancer Biology

Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts

Y. A. Yabo, P. M. Moreno-Sanchez, Y. Pires-Afonso, T. Kaoma, B. Nosirov, A. Scafidi, L. Ermini, A. Lipsa, A. Oudin, D. Kyriakis, K. Grzyb, S. K. Poovathingal, A. Poli, A. Muller, R. Toth, , A. Golebiewska

This study characterizes the tumor microenvironment in glioblastoma patient-derived xenografts and patient tumors, revealing phenotypic heterogeneity in microglia and their functional adaptations.

bioRxiv · Mar 5, 2023Cancer Biology

PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle

M. Benzarti, A. Oudin, E. Viry, E. Gargiulo, M. Schmoetten, L. Neises, C. Pulido, N. I. Lorenz, M. W. Ronellenfitsch, D. Sumpton, M. Warmoes, C. Jaeger, A. Lesur, J. Paggetti, E. Moussay, , J. Meiser

This study reveals that PKM2 inhibition redirects glycolytic and glutamine carbons into distinct metabolic pathways, supporting cancer cell metabolic flexibility under glycolytic limitation.

bioRxiv · Jan 23, 2023Cancer Biology

Primary and recurrent glioma patient-derived orthotopic xenografts (PDOX) represent relevant patient avatars for precision medicine

A. Golebiewska, A.-C. Hau, A. Oudin, D. Stieber, Y. A. Yabo, V. Baus, V. Barthelemy, E. Klein, S. Bougnaud, O. Keunen, M. Wantz, A. Michelucci, V. Neirinckx, A. Muller, T. Kaoma, , S. P. Niclou

This study shows that glioma PDOX models accurately represent patient tumors and can predict treatment responses in personalized medicine.

bioRxiv · Apr 24, 2020Cancer Biology