S. P. S. Wu

This study maps the epigenomic landscape of human myometrium at term pregnancy, identifying enhancers and regulatory elements associated with PGR and PLCL2.

The paper integrates ESR1 cistrome and transcriptome data from endometrial biopsies and organoids to identify estrogen-regulated genes and their functional roles in endometrial health.

This paper develops a mouse strain with decidua-specific Cre recombinase expression to study decidualization and infertility.

This study identifies WNK1's role in uterine homeostasis and pregnancy by showing its regulation of AKT signaling through PP2A in endometrial cells.

This study shows that increased FOXL2 expression in the female reproductive tract causes uterine structural and functional abnormalities, contributing to infertility and endometriosis progression.

The paper identifies novel genome variants associated with DYT1 dystonia through whole exome sequencing and suggests they may modify disease penetrance.

Term-pregnant versus nonpregnant human myometrium shows 2890 differentially expressed genes, more open chromatin regions (85777 vs 45501), and progesterone receptor binding shifted from promoters toward distal sites.

The paper identifies PGR-regulated genes and pathways in endometrium during the window of implantation using RNA-seq and PGR-ChIP-seq.

The paper identifies SYNE2 variants associated with earlier onset of DYT1 dystonia by affecting TOR1A-SYNE2 protein interactions in a family with TOR1A mutations.