Intestinal serotonergic vagal signaling as a mediator of microbiota-induced hypertension
Alan de Araujo, Hemaa Sree Kumar, Tao Yang, Emily Otmanowski, Adriana Alviter Plata, Elliott W. Dirr, Nicole R. Bearss, David Mark Baekey, Megan R. Dreier, Ivana L. de la Serna, Darren S. Miller, Başak Dönertaş Ayaz, Arashdeep Singh, Andrea L. Nestor‐Kalinoski, Timothy J. Garrett, , Jasenka A Zubcevic
This study identifies intestinal serotonergic vagal signaling as a key mediator of microbiota-induced hypertension, showing that reduced 5-HT and 5HT3aR signaling contributes to hypertension and can be reversed to alleviate it.
Circulation · Sep 15, 2026Peer-reviewedPhysiology