Multi-omics Analysis Identifies IgG2b Class-Switching with ALCAM-CD6 Co-Stimulation in Lymph Nodes During Advanced Inflammatory-Erosive Arthritis
H. M. Kenney, J. Rangel-Moreno, Y. Peng, K. L. Chen, J. Bruno, A. Embong, E. Pritchett, J. I. Fox, S. Quataert, G. Muthukrishnan, R. W. Wood, B. D. Korman, J. H. Anolik, L. Xing, C. T. Ritchlin, , C.-L. Wu
The paper identifies ALCAM-CD6 co-stimulation as a pathway promoting IgG2b class-switching in lymph nodes during advanced inflammatory arthritis using spatial and single-cell transcriptomics.
bioRxiv · Oct 27, 2022 · PreprintImmunology