E. M. Schwarz

The transcription factor ATML1 maintains giant cell identity by inducing synthesis of its own (very) long-chain fatty acid-containing ligands

The paper shows that high ATML1 concentrations induce VLCFA synthesis, which maintains giant cell identity by promoting auto-activation through lipid ligand binding.

A semi-automated cell tracking protocol for quantitative analyses of neutrophil swarming to sterile and S. aureus contaminated bone implants in a mouse femur model

This paper develops a semi-automated cell tracking protocol to quantify neutrophil swarming in a mouse femur model with and without S. aureus infection, showing increased speed, displacement, and directionality in infected mice.

Validation of Dual Energy X-ray Absorptiometry for longitudinal quantification of tumor burden in a murine model of pancreatic ductal adenocarcinoma

This study compares bioluminescent imaging and dual energy X-ray absorptiometry for longitudinal tumor burden quantification in a murine PDAC model, finding DEXA superior for tracking tumor growth and correlating with final tumor mass.

Multi-omics Analysis Identifies IgG2b Class-Switching with ALCAM-CD6 Co-Stimulation in Lymph Nodes During Advanced Inflammatory-Erosive Arthritis

The paper identifies ALCAM-CD6 co-stimulation as a pathway promoting IgG2b class-switching in lymph nodes during advanced inflammatory arthritis using spatial and single-cell transcriptomics.

High diversity and sharing of strongylid nematodes in humans and great apes co-habiting unprotected area in Cameroon

The paper identifies shared strongylid nematode communities between humans and great apes in Cameroon, highlighting parasite exchange outside protected areas.

Biphasic effects of IL-27 during Staphylococcus aureus implant-associated osteomyelitis in mice

This study identifies IL-27 as a biphasic cytokine with proinflammatory and anti-inflammatory roles during S. aureus osteomyelitis, suggesting it as a therapeutic target.

Ex vivo Demonstration of Functional Deficiencies in Popliteal Lymphatic Vessels from TNF-Tg Mice with Inflammatory Arthritis

This study examines functional deficiencies in popliteal lymphatic vessels from TNF-Tg mice with inflammatory arthritis, showing reduced contraction and flow parameters that are partially reversible with NOS inhibition.

Dual Energy X-ray Absorptiometry (DEXA) as a Longitudinal Outcome Measure of Cancer-Related Muscle Wasting in Mice

This study validates DEXA as a longitudinal measure of lean body mass and skeletal muscle wasting in a PDAC mouse model.

Timing of organ initiation is crucial for robust organ size

The paper shows that DRMY1 regulates sepal size in Arabidopsis by controlling organ initiation timing and growth.