Author

T. Scheidt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

C. K. Xu· 3 shared E. A. Lemke· 3 shared G. Meisl· 3 shared C. M. Dobson· 2 shared M. Brzezinski· 2 shared M. M. Schneider· 2 shared T. P. Knowles· 2 shared A. J. Priddey· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBiophysics

C. K. Xu

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6 papers

Recent·Most cited

Chaperone quality control in liquid-phase separated organelles

T. Scheidt, E. A. Lemke

This study shows that small heat shock proteins inhibit FUS and TDP-43 nano-cluster formation and target aggregation interfaces, highlighting their role in preventing neurodegenerative protein aggregation.

bioRxiv · Jan 23, 2024 · PreprintBiophysics

Protein-specific crowding accelerates aging in phase-separated droplets

M. Brzezinski, P. G. Argudo, T. Scheidt, M. Yu, E. A. Lemke, J. Michels, S. H. Parekh

This study shows that PEG affects phase-separated droplets differently depending on the protein, accelerating Nup98 maturation but stabilizing BSA droplets.

bioRxiv · Dec 10, 2023 · PreprintBiophysics

Role of Solvent Compatibility in the Phase Behavior of Binary Solutions of Weakly Associating Multivalent Polymers

J. J. Michels, M. Brzezinski, T. Scheidt, E. A. Lemke, S. Parekh

The paper investigates how solvent compatibility affects phase behavior in binary solutions of multivalent polymers, showing that it modulates isothermal liquid-liquid phase separation.

bioRxiv · Sep 9, 2021Biophysics

Microfluidic Antibody Affinity Profiling for In-Solution Characterisation of Alloantibody - HLA Interactions in Human Serum

M. M. Schneider, T. Scheidt, A. J. Priddey, C. K. Xu, M. Hu, S. R. A. Devenish, G. Meisl, C. M. Dobson, V. Kosmoliaptsis, T. P. J. Knowles

This paper develops a microfluidic assay to directly measure antibody affinity and concentration in solution, applied to characterise alloantibody-HLA interactions in transplant patient sera.

bioRxiv · Sep 14, 2020 · PreprintBiophysics

Templating S100A9 amyloids on Aβ fibrillar surfaces revealed by charge detection mass spectrometry, microscopy, kinetic and microfluidic analyses

J. Pansieri, I. A. Iashchishyn, H. Fakhouri, L. Ostojic, M. Malisauskas, G. Musteikyte, V. Smirnovas, M. M. Schneider, T. Scheidt, C. K. Xu, G. Meisl, T. P. Knowles, E. Gazit, R. Antoine, L. Morozova-Roche

The paper investigates the co-aggregation of S100A9 and Aβ42 amyloids using CDMS, microscopy, and kinetic analysis, revealing templating of S100A9 fibrils on Aβ42 surfaces.

bioRxiv · May 26, 2020Biophysics

Kinetic fingerprints differentiate anti-Aβ therapies

S. Linse, T. Scheidt, K. Bernfur, M. Vendruscolo, C. M. Dobson, S. I. Cohen, E. Sileikis, M. Lundquist, F. Qian, T. O'Malley, T. Bussiere, P. H. Weinreb, C. K. Xu, G. Meisl, S. Devenish, , O. Hansson

This study uses kinetic analysis and binding measurements to compare four anti-Aβ antibodies, showing aducanumab uniquely reduces Aβ oligomer flux.

bioRxiv · Feb 27, 2020 · PreprintBiophysics