Sphingosine 1-phosphate receptor 1 inhibition induces a pro-apoptotic signaling cascade in T cells
D. Dixit, V. M. Hallisey, E. Y. S. Zhu, M. Okuniewska, K. Cadwell, J. E. Chipuk, J. Axelrad, S. R. Schwab
This study shows that S1PR1 inhibition leads to T cell apoptosis by altering BCL2 family balance and JNK activity, with implications for immune responses in ulcerative colitis.
bioRxiv · Aug 21, 2023 · PreprintImmunology