Author

S. Rehan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

D. Tranter· 2 shared J. T. Huiskonen· 2 shared M. Javanainen· 2 shared V. Paavilainen· 2 shared A. Jennings· 1 shared C. J. Kirk· 1 shared C. Kalyanaraman· 1 shared D. McMinn· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

D. Tranter

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2 papers

Recent·Most cited

Molecular view of ER membrane remodeling by the Sec61/TRAP translocon

S. Karki, M. Javanainen, D. Tranter, S. Rehan, J. T. Huiskonen, L. Happonen, V. Paavilainen

The paper determines the structure of the Sec61/TRAP complex bound to a ribosome using Cryo-EM, revealing how TRAP facilitates ER membrane remodeling and polypeptide translocation.

bioRxiv · Sep 30, 2022Biochemistry

Signal peptide mimicry primes Sec61 for client-selective inhibition

S. Rehan, D. Tranter, P. P. Sharp, E. Lowe, J. Anderl, T. Muchamuel, V. Abrishami, S. Kuivanen, N. Wenzell, A. Jennings, C. Kalyanaraman, G. B. Craven, T. Strandin, M. Javanainen, O. Vapalahti, , V. Paavilainen

This study describes KZR-8445, a cyclic depsipeptide that selectively inhibits Sec61-mediated protein biogenesis by mimicking signal peptides, showing efficacy in a rheumatoid arthritis model.

bioRxiv · Jul 3, 2022Biochemistry