S. Kuivanen

Complete Protection from SARS-CoV-2 Lung Infection in Mice Through Combined Intranasal Delivery of PIKfyve Kinase and TMPRSS2 Protease Inhibitors

This study shows that combining PIKfyve and TMPRSS2 inhibitors intranasally protects mice from SARS-CoV-2 lung infection and reduces cell death.

Nanobody engineering for SARS-CoV-2 neutralization and detection

This study engineers nanobodies to neutralize SARS-CoV-2 variants and develop a detection assay, showing high potency against some variants but limitations against others.

Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the pre-hairpin intermediate of the spike protein

Signal peptide mimicry primes Sec61 for client-selective inhibition

This study describes KZR-8445, a cyclic depsipeptide that selectively inhibits Sec61-mediated protein biogenesis by mimicking signal peptides, showing efficacy in a rheumatoid arthritis model.

Proteome-wide cross-linking mass spectrometry to identify specific virus capsid-host interactions between tick-borne encephalitis virus and neuroblastoma cells

This paper identifies 59 high confidence virus-host protein interactions between tick-borne encephalitis virus and neuroblastoma cells using chemical cross-linking and mass spectrometry.

Antidepressant and antipsychotic drugs reduce viral infection by SARS-CoV-2 and fluoxetine show antiviral activity against the novel variants in vitro

This study tests antidepressants and antipsychotics against SARS-CoV-2 pseudoviruses and finds fluoxetine inhibits infection, including against variants with spike mutations.

Neuropilin-1 facilitates SARS-CoV-2 cell entry and provides a possible pathway into the central nervous system

This study shows that neuropilin-1 enhances SARS-CoV-2 infectivity and facilitates viral entry into the central nervous system via the olfactory pathway.

Critical Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis

This study identifies critical host-virus interaction nodes through network analysis and drug re-purposing, revealing key targets for antiviral therapies.