DNA methylation mediated downregulation of histone H3 variant H3.3 affects cell proliferation contributing to the development of HCC
S. Gupta, D. Reddy, S. Bhattacharya…·M. Rashid
The paper shows that DNA methylation reduces H3.3 levels in HCC, affecting transcription and cell proliferation, and suggests DNMT and HDAC inhibitors as potential therapies.