Author

N. Basisty

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 2 Immunology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 8 Research Focus:cell type annotation· 7 Approach:experimental assay· 5 Research Focus:differential expression· 4 Organism:human· 4 Approach:deep learning· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

B. Schilling· 7 shared J. Bons· 3 shared J. Campisi· 3 shared J. Rose· 3 shared S. Shah· 3 shared A. Kale· 2 shared C. Rao· 2 shared P. Gascard· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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7 shared papersCell Biology

B. Schilling

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Concerted epithelial and stromal changes during progression of Barrett's Esophagus to invasive adenocarcinoma exposed by multi-scale, multi-omics analysis

M. Strasser, D. L. Gibbs, P. Gascard, J. Bons, J. W. Hickey, C. M. Schürch, Y. Tan, S. Black, P. Chu, A. Ozkan, N. Basisty, V. Sangwan, J. Rose, S. Shah, S. Camilleri-Broet, , L. L. Ferri

This study uses multi-omics analysis to show coordinated changes in epithelial, stromal, and immune compartments during Barrett's Esophagus progression to adenocarcinoma, revealing early appearance of cancer-associated fibroblasts and immunosuppressive microenvironment.

bioRxiv · Jun 8, 2023 · PreprintCancer Biology

Data-Independent Acquisition and Quantification of Extracellular Matrix from Human Lung in Chronic Inflammation-Associated Carcinomas

J. Bons, D. Pan, S. Shah, R. Bai, C. Chen-Tanyolac, X. Wang, D. R. Fels Elliott, A. Urisman, A. O'Broin, N. Basisty, J. Rose, V. Sangwan, S. Camilleri-Broet, J. Tankel, P. Gascard, , B. Schilling

The paper develops a proteomic pipeline to analyze ECM remodeling in lung squamous cell carcinoma, identifying 529 differentially expressed proteins and potential biomarkers.

bioRxiv · Aug 5, 2022Cancer Biology

Comprehensive Proteomic Quantification of Bladder Stone Progression in a Cystinuric Mouse Model Using Data-Independent Acquisitions

J. Rose, N. Basisty, T. Zee, C. Wehrfritz, N. Bose, P.-Y. Desprez, P. Kapahi, M. Stoller, B. Schilling

This study uses proteomic analysis in a cystinuria mouse model to identify proteomic changes during bladder stone progression, highlighting key pathways involved in stone growth and recurrence.

bioRxiv · Apr 6, 2021 · PreprintCell Biology

Comprehensive Profiling of Plasma Exosomes Using Data Independent Acquisitions, New Tools for Aging Cohort Studies

S. K. Patel, R. Bruderer, N. Basisty, J. Bons, P.-Y. Desprez, F. Neri, L. Reiter, J. Campisi, B. Schilling

The paper develops a method to isolate and analyze plasma exosomes, identifying age-related protein and miRNA differences in an aging cohort.

bioRxiv · Feb 27, 2021 · PreprintCell Biology

Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice

Y. A. Chiao, H. Zhang, M. Sweetwyne, J. Whitson, Y. S. Ting, N. Basisty, L. Pino, E. Quarles, N.-H. Nguyen, M. Campbell, T. Zhang, M. J. Gaffrey, G. Merrihew, L. Wang, Y. Yue, , P. S. Rabinovitch

This study shows that treating old mice with SS-31 improves cardiac diastolic function by reducing mitochondrial oxidative stress and restoring redox balance.

bioRxiv · Jan 2, 2020Physiology

A Proteomic Atlas of Senescence-Associated Secretomes for Aging Biomarker Development

N. Basisty, A. Kale, O. Jeon, C. Kuehnemann, T. Payne, C. Rao, A. Holtz, S. Shah, V. Sharma, L. Ferrucci, J. Campisi, B. Schilling

The paper develops a proteomic atlas of senescence-associated secretomes to identify aging biomarkers, finding that GDF15, STC1, and SERPINs correlate with age in human plasma.

bioRxiv · Aug 21, 2019Cell Biology

Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38+ macrophages

A. J. Covarrubias, A. Kale, R. Perrone, J. A. Lopez-Dominguez, A. Oliveira Pisco, H. G. Kasler, M. S. Schmidt, C. D. Wiley, S. S. Iyer, N. Basisty, Q. Wu, R. Kwok, I. Heckenbach, K.-O. Shin, Y.-M. Lee, , E. Verdin

This study identifies CD38+ macrophages as a driver of NAD decline during aging through inflammation linked to cellular senescence in metabolic tissues.

bioRxiv · Jul 31, 2019Immunology

Global lysine acetylation in Escherichia coli results from growth conditions that favor acetate fermentation

B. Schilling, N. Basisty, D. G. Christensen, D. Sorensen, J. S. Orr, A. J. Wolfe, C. Rao

This study shows that lysine acetylation in E. coli is primarily influenced by sugar concentration rather than the type of sugar, with higher concentrations leading to more acetylation.

bioRxiv · Oct 31, 2018Microbiology