T. Mueller

ThirdPeak: A flexible tool designed for the robust analysis of two- and three-dimensional (single-molecule) tracking data.

ThirdPeak analyzes 2D and 3D single-molecule tracking data, revealing insights from combined 2D and 3D analysis of live-cell diffusion.

Plant infection by the necrotrophic fungus Botrytis requires actin-dependent generation of high invasive turgor pressure

This study shows Botrytis uses actin-dependent invasive pressure and surface adherence to penetrate plant cells, reducing virulence when actin polymerization is blocked.

The second messenger c-di-AMP controls natural competence via ComFB signaling protein

The paper shows that c-di-AMP regulates natural competence in cyanobacteria via the ComFB signaling protein, which is essential for pilus biogenesis and DNA uptake.

A single-sample workflow for joint metabolomic and proteomic analysis of clinical specimens

The paper introduces a single-sample workflow, MTBE-SP3, for simultaneous proteomic and metabolomic analysis, showing it reduces technical variation and enables consistent results across biological matrices.

Continuous endosomes form functional subdomains and orchestrate rapid membrane trafficking in trypanosomes

The paper investigates the endosomal system in Trypanosoma brucei, revealing it as a continuous membrane system rather than distinct compartments, enabling rapid membrane trafficking.

Dog population estimates and rabies vaccination optimization using the High Resolution Settlement Layer (HRSL) - a proof of principle for the Oshana region, Namibia

The paper uses high-resolution geospatial data to estimate dog populations and optimize rabies vaccination strategies in the Oshana region of Namibia.

Ontogeny shapes individual specialization

The paper investigates the ontogeny of individual dietary specialization in European brown bears, finding social learning and maternal effects are key drivers.

Alpha-synuclein oligomers displace monomeric alpha-synuclein from lipid membranes

This study shows that alpha-synuclein oligomers bind more strongly to curved lipid membranes and displace monomeric alpha-synuclein, suggesting a new mechanism for Parkinson's disease toxicity.

Nomadic ungulate movements under threat: Declining mobility of Mongolian gazelles in the Eastern Steppe.

This study shows that Mongolian gazelles have reduced long-distance movement by 36% over 15 years due to increasing vehicle traffic, despite no physical barriers.

Lipid Droplets Fuel Small Extracellular Vesicle Biogenesis

This study shows that lipid droplets are linked to small extracellular vesicle biogenesis and that manipulating lipid droplets can affect sEV secretion and cargo.

Genome wide CRISPR screen for Pasteurella multocida toxin (PMT) binding proteins reveals LDL Receptor Related Protein1 (LRP1) as crucial cellular receptor

The paper identifies LRP1 as a critical receptor for PMT toxin entry into cells using a CRISPR screen, showing its role in toxin binding and G protein activation.

Pre-analytical processing of plasma and serum samples for combined proteome and metabolome analysis

This study evaluates pre-analytical factors affecting plasma and serum proteome and metabolome stability, recommending standardized protocols for clinical use.

Oral rabies vaccination of dogs - experiences from a field trial in Namibia

This paper reports on a field trial in Namibia evaluating oral rabies vaccination (ORV) of dogs using a third-generation vaccine and egg-flavoured bait, showing high bait uptake and vaccination rates.

Classifying the activity states of small vertebrates using automated VHF telemetry

This paper develops a random forest model to classify activity states of small vertebrates using VHF telemetry signals, achieving high accuracy across species.

Adipose cells and tissues soften with lipid accumulation while in diabetes adipose tissue stiffens

This study investigates how adipocyte shape, size, and lipid accumulation affect mechanical properties of adipose tissue in health, obesity, and diabetes.

Gene edited fluorescent cerebral organoids to study human brain function and disease

The paper introduces a method using gene-edited fluorescent cerebral organoids to study human brain function and disease by reducing inter-organoid variability through mixed cell line labeling.

Neuroglia Infection by Rabies Virus after Anterograde Virus Spread in Peripheral Neurons

This study identifies Schwann cells as targets of field rabies virus in peripheral nerves, revealing anterograde spread and a role in suppressing innate immunity.

Multi-species ELISA for the detection of antibodies against SARS-CoV-2 in animals

The paper develops a multi-species ELISA to detect SARS-CoV-2 antibodies in animals, achieving 100% specificity and 98.31% sensitivity across multiple species.

Susceptibility of raccoon dogs for experimental SARS-CoV-2 infection

This study shows raccoon dogs are susceptible to SARS-CoV-2 infection and can transmit it to direct contact animals, suggesting they may act as intermediate hosts.

A comprehensive framework for handling location error in animal tracking data

This paper introduces a framework for handling location error in animal tracking data, showing that error-model selection improves analysis accuracy across various tracking devices and species.

Glycosaminoglycans are specific endosomal receptors for Yersinia pseudotuberculosis Cytotoxic Necrotizing Factor

This paper identifies heparan sulfate proteoglycans as essential host factors for Yersinia pseudotuberculosis CNFY toxin intoxication, showing that conformational changes and heparanase activity are critical for toxin uptake and function.

Community-wide seed dispersal distances peak at low levels of specialisation in size-structured networks

The paper links ecological interaction networks to a trait-based seed-dispersal model to show that dispersal distances peak at low levels of niche partitioning.

Comparative analysis of genetic diversity and differentiation of cauliflower (Brassica oleracea var. botrytis) accessions from two ex situ genebanks

This study compares genetic diversity and differentiation between two cauliflower genebanks using GBS, finding that accession composition, not regeneration procedures, drives genetic structure and diversity loss.