Author

S. Spelier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Approach:experimental assay· 1 Approach:microscopy & imaging analysis· 1 Assay:organoid / primary culture· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

A. Akhmanova· 1 shared A. Vonk· 1 shared D. C. M. de Jong· 1 shared D. Muijlwijk· 1 shared E. de Poel· 1 shared E. J. van Grinsven· 1 shared E. Kruisselbrink· 1 shared G. D. Amatngalim· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCell Biology

A. Akhmanova

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Author profile →

2 papers

Recent·Most cited

High-Throughput Functional Assay in Cystic Fibrosis Patient-Derived Organoids Allows Drug Repurposing

S. Spelier, E. de Poel, G. N. Ithakisiou, S. Suen, M. Hagemeijer, D. Muijlwijk, A. Vonk, J. Brunsveld, E. Kruisselbrink, K. van der Ent, J. Beekman

This study uses a high-throughput functional assay in patient-derived organoids to screen FDA-approved drugs for CFTR function restoration in rare mutations, finding statins enhance CFTR function specifically in W1282X mutations.

bioRxiv · Jul 14, 2022Cell Biology

Optical nanoscopy reveals SARS-CoV-2-induced remodeling of human airway cells

W. Nijenhuis, H. G. J. Damstra, E. J. van Grinsven, M. K. Iwanski, P. Praest, Z. E. Soltani, M. M. P. van Grinsven, J. E. Brunsveld, T. M. De Kort, L. W. Rodenburg, D. C. M. de Jong, H. M. Raeven, S. Spelier, G. D. Amatngalim, A. Akhmanova, , L. C. M. Kapitein

This study uses advanced microscopy to show how SARS-CoV-2 changes the structure of human airway cells at the subcellular level.

bioRxiv · Aug 5, 2021 · PreprintCell Biology