Author

E. Kruisselbrink

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:organoid / primary culture· 2

Frequent Co-Authors

J. Brunsveld· 2 shared A. Vonk· 1 shared B. L. Aalbers· 1 shared C. K. van der Ent· 1 shared C. M. van Drunen· 1 shared D. Muijlwijk· 1 shared E. de Poel· 1 shared E. M. Aarts· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

J. Brunsveld

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Author profile →

2 papers

Recent·Most cited

High-Throughput Functional Assay in Cystic Fibrosis Patient-Derived Organoids Allows Drug Repurposing

S. Spelier, E. de Poel, G. N. Ithakisiou, S. Suen, M. Hagemeijer, D. Muijlwijk, A. Vonk, J. Brunsveld, E. Kruisselbrink, K. van der Ent, J. Beekman

This study uses a high-throughput functional assay in patient-derived organoids to screen FDA-approved drugs for CFTR function restoration in rare mutations, finding statins enhance CFTR function specifically in W1282X mutations.

bioRxiv · Jul 14, 2022Cell Biology

Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia

G. D. Amatngalim, L. W. Rodenburg, B. L. Aalbers, H. H. M. Raeven, E. M. Aarts, I. A. L. Silva, W. Nijenhuis, S. Vrendenbarg, E. Kruisselbrink, J. Brunsveld, C. M. van Drunen, S. Michel, K. M. de Winter-de Groot, H. G. Heijerman, L. C. Kapitein, , J. M. Beekman

This study develops an improved method to measure CFTR drug responses in nasal airway organoids derived from 2D differentiated epithelial cells.

bioRxiv · Jul 20, 2021Cell Biology