P. Friedl

Multi-site assessment of reproducibility in high-content live cell imaging data

This study assesses reproducibility in high-content live cell imaging data across multiple sites and identifies sources of variability, showing that batch correction improves meta-analysis of perturbation experiments.

Extracellular matrix guidance determines proteolytic and non-proteolytic cancer cell patterning

This study shows that matrix density and guidance cues determine whether cancer cells use proteolytic or non-proteolytic invasion strategies in 3D tissue.

Intravital Deep-Tumor Single-Beam 2-, 3- and 4-Photon Microscopy

This paper demonstrates that high-pulse-energy low-duty-cycle infrared excitation enables deeper tissue penetration in tumors and bone compared to conventional 2-photon excitation, allowing simultaneous multi-parameter imaging.

Post-EMT: Cadherin-11 mediates cancer hijacking fibroblasts

This study identifies cadherin-11 as a mediator of cancer cell hijacking of fibroblasts post-EMT, enhancing invasion and metastasis in solid tumors.

Glycocalyx-mediated Cell Adhesion and Migration

This study shows the glycocalyx enables cell adhesion and amoeboid migration through nanoscale interactions and mechano-coupling, independent of integrin function.

Cancer cell elimination by cytotoxic T cell cooperation and additive damage

The paper shows that cytotoxic T cells eliminate cancer cells through multiple sublethal interactions rather than a single lethal hit, highlighting additive cytotoxicity in vivo.

Lamin B2 follows lamin A/C- mediated nuclear mechanics and cancer cell invasion efficacy

The paper investigates the role of lamin B2 in nuclear mechanics and cancer cell invasion, finding that lamin B2 cooperates with lamin A/C to regulate nuclear deformability and migration efficacy.

An Active Chemo-mechanical Model to Predict Adhesion and Microenvironmental Regulation of 3D Cell Shapes

This study develops a chemo-mechanical model to predict how adhesions and microenvironmental properties regulate 3D cell shapes, validated with experiments on HT1080 cells and literature data.

Calpain-2 regulates hypoxia/HIF-induced amoeboid reprogramming and metastasis

This study identifies calpain-2 as a regulator of hypoxia-induced amoeboid reprogramming and metastasis in breast and head and neck cancers.

Leader cell activity and collective invasion by an autocrine nucleotide loop through connexin-43 hemichannels and ADORA1

The paper identifies Cx43/ADORA1 autocrine signaling as critical for leader cell activity and collective invasion in breast cancer.