Antibody-mediated prevention of vaginal HIV transmission is dictated by IgG subclass in humanized mice
J. M. Brady, M. Phelps, S. W. MacDonald, E. C. Lam, A. Nitido, D. Parsons, C. L. Boutros, C. E. Deal, S. Tanno, H. Natarajan, M. E. Ackerman, V. D. Vrbanac, A. B. Balazs
The paper investigates the role of IgG subclasses in HIV prevention using humanized mice, finding that VRC07-IgG1 provides substantial protection despite low concentrations.
bioRxiv · Jul 7, 2022Immunology