A. B. Balazs

Immune Signatures of SARS-CoV-2 Infection Resolution in Human Lung Tissues

This study identifies immune signatures associated with SARS-CoV-2 infection resolution in human lung tissues using a humanized mouse model.

Heterologous sarbecovirus receptor binding domains as scaffolds for SARS-CoV-2 receptor binding motif presentation

This study designs immunogens by grafting SARS-2 RBM onto heterologous sarbecovirus scaffolds to elicit broad neutralizing antibodies against sarbecoviruses.

Maternally transferred monoclonal antibodies protect neonatal mice from herpes simplex virus-induced mortality and morbidity

This study shows that HSV-specific monoclonal antibodies transferred from mothers or directly administered to neonatal mice reduce HSV-induced mortality and morbidity.

Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds

This study shows DNA origami scaffolds enhance antibody responses to SARS-CoV-2 RBD without inducing immune memory against the scaffold itself, compared to protein-based VLPs.

Antibody-mediated prevention of vaginal HIV transmission is dictated by IgG subclass in humanized mice

The paper investigates the role of IgG subclasses in HIV prevention using humanized mice, finding that VRC07-IgG1 provides substantial protection despite low concentrations.

Comprehensive antibody profiling of mRNA vaccination in children

This study compares humoral immune responses to mRNA vaccines in children aged 6-11 years, finding that a 100g dose elicits robust and dose-dependent cross-VOC antibody responses with preserved functional immunity.

Macrophages govern antiviral responses in human lung tissues protected from SARS-CoV-2 infection

This study shows that macrophages mediate antiviral responses in human lung tissues, protecting against SARS-CoV-2 infection through the USP18-ISG15 axis.

TAILORED DC INDUCE PROTECTIVE HIV-1 SPECIFIC POLYFUNCTIONAL CD8+ T CELLS IN THE LYMPHOID TISSUE FROM HUMANIZED BLT MICE

This study shows that TBK1-primed dendritic cells reduce HIV-1 disease progression in humanized mice by enhancing CD8+ T cell responses.

Rationally designed immunogens enable immune focusing to the SARS-CoV-2 receptor binding motif

This study designs immunogens that focus immune responses to the SARS-CoV-2 receptor binding motif, enhancing neutralizing antibody breadth against related sarbecoviruses.

Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses

The paper isolates naive B cells targeting SARS-CoV-2 RBD and shows they can neutralize the virus and variants.

Engineered receptor binding domain immunogens elicit pan-sarbecovirus neutralizing antibodies

This study shows that a cocktail of trimeric sarbecovirus receptor binding domains elicits broadly neutralizing antibodies against multiple sarbecoviruses, including in the context of prior SARS-CoV-2 immunity.

Multi-Modal Profiling of Human Fetal Liver-Derived Hematopoietic Stem Cells Reveals the Molecular Signature of Engraftment Potential

The paper profiles human fetal liver hematopoietic stem cells using multi-modal data to identify a molecular signature associated with engraftment potential.

Protocol and reagents for pseudotyping lentiviral particles with SARS-CoV-2 Spike protein for neutralization assays

This paper provides a protocol for pseudotyping lentiviral particles with SARS-CoV-2 Spike protein to measure neutralizing antibody activity in a luciferase-based assay.