Author

E. C. Lam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

A. B. Balazs· 6 shared B. M. Hauser· 4 shared D. Lingwood· 4 shared M. Sangesland· 4 shared A. G. Schmidt· 3 shared J. Feldman· 3 shared K. J. St. Denis· 3 shared T. Kannegieter· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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6 shared papersImmunology

A. B. Balazs

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Author profile →

6 papers

Recent·Most cited

Heterologous sarbecovirus receptor binding domains as scaffolds for SARS-CoV-2 receptor binding motif presentation

B. M. Hauser, M. Sangesland, E. C. Lam, K. J. St. Denis, M. L. Sheehan, M. L. Vu, A. H. Cheng, A. B. Balazs, D. Lingwood, A. Schmidt

This study designs immunogens by grafting SARS-2 RBM onto heterologous sarbecovirus scaffolds to elicit broad neutralizing antibodies against sarbecoviruses.

bioRxiv · Aug 21, 2023Immunology

Antibody-mediated prevention of vaginal HIV transmission is dictated by IgG subclass in humanized mice

J. M. Brady, M. Phelps, S. W. MacDonald, E. C. Lam, A. Nitido, D. Parsons, C. L. Boutros, C. E. Deal, S. Tanno, H. Natarajan, M. E. Ackerman, V. D. Vrbanac, A. B. Balazs

The paper investigates the role of IgG subclasses in HIV prevention using humanized mice, finding that VRC07-IgG1 provides substantial protection despite low concentrations.

bioRxiv · Jul 7, 2022Immunology

Comprehensive antibody profiling of mRNA vaccination in children

Y. C. Bartsch, K. J. St Denis, P. Kaplonek, J. Kang, E. C. Lam, M. D. Burns, E. J. Farkas, J. Davis, B. Boribong, A. G. Edlow, A. Fasano, W. Shreffler, D. Zavadska, M. Johnson, D. Goldblatt, , A. Galit

This study compares humoral immune responses to mRNA vaccines in children aged 6-11 years, finding that a 100g dose elicits robust and dose-dependent cross-VOC antibody responses with preserved functional immunity.

bioRxiv · Oct 7, 2021 · PreprintImmunology

Rationally designed immunogens enable immune focusing to the SARS-CoV-2 receptor binding motif

B. M. Hauser, M. Sangesland, K. J. St. Denis, I. W. Windsor, J. Feldman, E. C. Lam, T. Kannegieter, A. B. Balazs, D. Lingwood, A. G. Schmidt

This study designs immunogens that focus immune responses to the SARS-CoV-2 receptor binding motif, enhancing neutralizing antibody breadth against related sarbecoviruses.

bioRxiv · Mar 15, 2021 · PreprintImmunology

Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses

J. Feldman, J. Bals, C. Altomare, K. S. Denis, E. C. Lam, B. M. Hauser, L. Ronsard, M. Sangesland, T. B. Moreno, V. Okonkwo, N. Hartojo, A. B. Balazs, G. Bajic, D. Lingwood, A. G. Schmidt

The paper isolates naive B cells targeting SARS-CoV-2 RBD and shows they can neutralize the virus and variants.

bioRxiv · Feb 2, 2021Immunology

Engineered receptor binding domain immunogens elicit pan-sarbecovirus neutralizing antibodies

B. M. Hauser, M. Sangesland, E. C. Lam, K. J. St. Denis, J. Feldman, A. S. Yousif, T. M. Caradonna, T. Kannegieter, A. B. Balazs, D. Lingwood, A. G. Schmidt

This study shows that a cocktail of trimeric sarbecovirus receptor binding domains elicits broadly neutralizing antibodies against multiple sarbecoviruses, including in the context of prior SARS-CoV-2 immunity.

bioRxiv · Dec 7, 2020 · PreprintImmunology