A non-canonical arm of UPRER mediates longevity through ER remodeling and lipophagy.
J. R. Daniele, R. Higuchi-Sanabria, V. Ramachandran, M. Sanchez, J. Durieux, S. U. Tronnes, J. W. Paul, D. J. Esping, S. Monshietehadi, M. G. Metcalf, A. Dillin
This study identifies a non-canonical UPRER pathway that extends lifespan through ER remodeling and lipophagy, independent of chaperone function.
bioRxiv · Nov 15, 2018 · PreprintCell Biology