Author

R. Higuchi-Sanabria

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 4 Research Focus:development & morphogenesis· 4 Assay:proteomics· 3 Organism:C. elegans· 2 Research Focus:cell type annotation· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

A. Dillin· 4 shared C. K. Tsui· 3 shared G. Garcia· 3 shared A. Alcala· 2 shared M. Averbukh· 2 shared N. Dutta· 2 shared T. C. Torres· 2 shared A. Coughlin· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersCell Biology

A. Dillin

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Investigating impacts of marine sponge derived mycothiazole and its acetylated derivative on mitochondrial function and aging.

N. Dutta, J. A. Gerke, S. F. Ordon, J. D. Morris, A. Hruby, T. C. Torres, S. Shemtov, J. G. Clark, M. C. Chang, H. Shaghasi, M. N. Ray, M. Averbukh, S. Hoang, M. Oorloff, A. Alcala, , R. Higuchi-Sanabria

This study investigates the effects of marine sponge-derived mycothiazole and its acetylated derivative on mitochondrial function and aging using in vitro and in vivo models.

bioRxiv · Nov 27, 2023Cell Biology

Lipid homeostasis is essential for a maximal ER stress response

G. Garcia, H. Zhang, S. Moreno, C. K. Tsui, B. M. Webster, R. Higuchi-Sanabria, A. Dillin

This study identifies let-767 as a gene critical for lipid and ER protein homeostasis, showing that lipid metabolism influences the ER stress response.

bioRxiv · Oct 27, 2022Cell Biology

Large-scale genetic screens identify BET-1 as a cytoskeleton regulator promoting actin health and lifespan.

G. Garcia, R. Bar-Ziv, N. Dutta, D. Moaddeli, M. Averbukh, T. C. Torres, A. Alcala, C. K. Tsui, E. A. Moehle, O. Shalem, M. Thorwald, R. Higuchi-Sanabria

The paper identifies BET-1 as a regulator of actin health and lifespan through genetic screens in human fibroblasts and C. elegans.

bioRxiv · Jun 22, 2022 · PreprintCell Biology

Identification of a novel modulator of the actin cytoskeleton, mitochondria, nutrient metabolism and lifespan in yeast

C. N. Sing, E. J. Garcia, T. Lipkin, T. Huckaba, C. A. Tsang, A. Coughlin, E. J. Yang, I. R. Boldogh, R. Higuchi-Sanabria, L. Pon

The paper identifies YKL075C as a novel modulator affecting actin cable stability, mitochondrial function, nutrient metabolism, and yeast lifespan.

bioRxiv · Oct 7, 2021Cell Biology

Measuring expression heterogeneity of single-cell cytoskeletal protein complexes

J. Vlassakis, L. L. Hansen, R. Higuchi-Sanabria, Y. Zhou, C. K. Tsui, A. Dillin, H. Huang, A. E. Herr

The paper introduces a method to measure single-cell cytoskeletal protein complex expression heterogeneity and finds some cells upregulate other cytoskeletal complexes in response to stress.

bioRxiv · Sep 12, 2020Bioengineering

Adhesion-mediated mechanosignaling forces mitohormesis

K. M. Tharp, R. Higuchi-Sanabria, G. Timblin, B. Ford, C. Garzon-Coral, C. Schneider, J. M. Muncie, C. Stashko, J. Daniele, A. S. Moore, P. Frankino, S. Manoli, H. Shao, A. L. Richards, K.-H. Chen, , V. M. Weaver

The paper shows that adhesion-mediated mechanosignaling activates a mitochondrial stress response through SLC9A1 and HSF1, altering mitochondrial function in aging and cancer.

bioRxiv · Mar 6, 2020Cell Biology

A non-canonical arm of UPRER mediates longevity through ER remodeling and lipophagy.

J. R. Daniele, R. Higuchi-Sanabria, V. Ramachandran, M. Sanchez, J. Durieux, S. U. Tronnes, J. W. Paul, D. J. Esping, S. Monshietehadi, M. G. Metcalf, A. Dillin

This study identifies a non-canonical UPRER pathway that extends lifespan through ER remodeling and lipophagy, independent of chaperone function.

bioRxiv · Nov 15, 2018 · PreprintCell Biology