J. Durieux

The UPRmt Preserves Mitochondrial Import to Extend Lifespan

This study shows that activating the UPRmt through ATFS-1 increases mitochondrial import efficiency, preserves import capacity with age, and extends lifespan in worms.

A non-canonical arm of UPRER mediates longevity through ER remodeling and lipophagy.

This study identifies a non-canonical UPRER pathway that extends lifespan through ER remodeling and lipophagy, independent of chaperone function.