Author

S. Velho

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

F. Martins· 4 shared M. J. Oliveira· 4 shared J. Carvalho· 3 shared A. L. Machado· 2 shared A. Ribeiro· 2 shared P. Dias Carvalho· 2 shared S. Mendonca· 2 shared A. Roma· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersCancer Biology

F. Martins

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4 papers

Recent·Most cited

Unveiling the Mechanisms to Bypass KRAS Inhibition: In Vitro Insights into the Influence of Fibroblast-Secretome

S. M. Oliveira, P. D. Carvalho, A. Roma, P. Oliveira, A. Ribeiro, J. Carvalho, F. Martins, A. L. Machado, M. J. Oliveira, S. Velho

This study investigates how fibroblast-secreted factors promote KRAS-independent stemness in KRAS-mutant CRC cells, revealing a mechanism by which the tumor microenvironment contributes to resistance to KRAS inhibition.

bioRxiv · Apr 19, 2024 · PreprintCancer Biology

Modulation of fibroblasts phenotype by colorectal cancer cells-secreted factors is mostly independent of oncogenic KRAS

P. Dias Carvalho, S. Mendonca, F. Martins, M. J. Oliveira, S. Velho

This study shows that mutant KRAS in colorectal cancer cells has a limited role in modulating fibroblast pro-tumorigenic features, suggesting KRAS-independent mechanisms may drive fibroblast activation and resistance to KRAS inhibitors.

Cells · Aug 11, 2022Peer-reviewedCancer Biology

Mutant KRAS-associated proteome is mainly controlled by exogenous factors

P. Dias Carvalho, F. Martins, J. Carvalho, M. J. Oliveira, S. Velho

The paper investigates how exogenous factors influence the KRAS-associated proteome in mutant KRAS colorectal cancer cell lines, finding that most of the proteome changes are non-autonomous and dependent on external signals.

bioRxiv · Jan 5, 2022Cancer Biology

Mutant KRAS modulates colorectal cancer cells invasive response to fibroblast-secreted factors through the HGF/C-MET axis

P. Dias-Carvalho, F. Martins, S. Mendonca, A. Ribeiro, A. L. Machado, J. Carvalho, M. J. Oliveira, S. Velho

This study shows mutant KRAS modulates colorectal cancer cell invasion via the HGF/C-MET axis, influenced by fibroblast-secreted factors.

bioRxiv · Nov 16, 2021Cancer Biology