J. Carvalho

Unveiling the Mechanisms to Bypass KRAS Inhibition: In Vitro Insights into the Influence of Fibroblast-Secretome

This study investigates how fibroblast-secreted factors promote KRAS-independent stemness in KRAS-mutant CRC cells, revealing a mechanism by which the tumor microenvironment contributes to resistance to KRAS inhibition.

Parallel evolution of local adaptation in Littorina saxatilis inferred with whole-genome pool-seq data

The paper uses whole-genome pool-seq data and approximate Bayesian computation to show parallel ecotype formation in Littorina saxatilis across Spain and Sweden despite gene flow.

Mutant KRAS-associated proteome is mainly controlled by exogenous factors

The paper investigates how exogenous factors influence the KRAS-associated proteome in mutant KRAS colorectal cancer cell lines, finding that most of the proteome changes are non-autonomous and dependent on external signals.

Mutant KRAS modulates colorectal cancer cells invasive response to fibroblast-secreted factors through the HGF/C-MET axis

This study shows mutant KRAS modulates colorectal cancer cell invasion via the HGF/C-MET axis, influenced by fibroblast-secreted factors.

Epithelial-mesenchymal plasticity induced by discontinuous exposure to TGFβ1 promotes tumour growth

The paper shows that discontinuous TGFβ1 exposure induces EMT/MET transitions in EpH4 cells, leading to RE-cells with molecular and functional heterogeneity that promotes tumour growth.

Bayesian Connective Field Modeling: a Markov Chain Monte Carlo approach.

This paper introduces a Bayesian framework for Connective Field modeling using MCMC to quantify parameter uncertainty and analyze human visual cortex connectivity.

Predicting range shifts of African apes under global change scenarios

The paper predicts future distribution shifts of African apes under climate and land-use change scenarios using ensemble forecasting and occurrence data.

A novel antibody targeting ICOS increases intratumoural cytotoxic to regulatory T cell ratio and induces tumour regression.

This paper develops an antibody targeting ICOS that improves the TEFF:TReg ratio and induces tumour regression in preclinical models.