F. Martins

Unveiling the Mechanisms to Bypass KRAS Inhibition: In Vitro Insights into the Influence of Fibroblast-Secretome

This study investigates how fibroblast-secreted factors promote KRAS-independent stemness in KRAS-mutant CRC cells, revealing a mechanism by which the tumor microenvironment contributes to resistance to KRAS inhibition.

Fucose is an essential feature in cryoprotective polysaccharides

The paper evaluates 26 natural polysaccharides as cryoprotective agents, finding that fucose-rich polysaccharides significantly enhance post-thaw metabolic viability of Vero cells compared to other types.

KRAB zinc finger proteins ZNF587/ZNF417 protect lymphoma cells from replicative stress-induced inflammation

This study identifies ZNF587 and ZNF417 as pro-oncogenic factors in DLBCL that reduce replicative stress and inflammation, promoting cancer cell survival and immune evasion.

Modulation of the functional interfaces between retroviral intasomes and the human nucleosome

The paper develops an alphaLISA assay to study intasome-nucleosome interactions, identifies compounds that modulate this interaction, and shows their antiviral effects against PFV and HIV-1.

Modulation of fibroblasts phenotype by colorectal cancer cells-secreted factors is mostly independent of oncogenic KRAS

This study shows that mutant KRAS in colorectal cancer cells has a limited role in modulating fibroblast pro-tumorigenic features, suggesting KRAS-independent mechanisms may drive fibroblast activation and resistance to KRAS inhibitors.

THE MAJOR ROLE OF JUNCTIONAL DIVERSITY IN THE HORSE ANTIBODY REPERTOIRE

This study characterizes the horse antibody heavy chain repertoire, revealing high junctional diversity and limited VJ gene usage, highlighting its role in generating antibody variability.

Mutant KRAS-associated proteome is mainly controlled by exogenous factors

The paper investigates how exogenous factors influence the KRAS-associated proteome in mutant KRAS colorectal cancer cell lines, finding that most of the proteome changes are non-autonomous and dependent on external signals.

Mutant KRAS modulates colorectal cancer cells invasive response to fibroblast-secreted factors through the HGF/C-MET axis

This study shows mutant KRAS modulates colorectal cancer cell invasion via the HGF/C-MET axis, influenced by fibroblast-secreted factors.

Nuclear HMGB1 protects from non-alcoholic fatty liver diseases through negative regulation of liver X receptor

This study shows that nuclear HMGB1 suppresses liver lipogenesis in NAFLD by inhibiting LXR activity, preventing steatosis and insulin resistance.

DNA damage independent inhibition of NF-κB transcription by anthracyclines

This study shows anthracyclines inhibit NF-κB transcription without DNA damage, affecting inflammation independently of their DNA-damaging effects.

Detecting fine and elaborate movements with piezo sensors, from heartbeat to the temporal organization of behavior

The paper introduces a novel device, Phenotypix, that detects fine movements in rodents using piezo sensors and combines it with video and machine learning to analyze behavioral dynamics.