Cancer BiologyCellsPeer-reviewed
Modulation of fibroblasts phenotype by colorectal cancer cells-secreted factors is mostly independent of oncogenic KRAS
P. Dias Carvalho, S. Mendonca, F. Martins…·S. Velho
This study shows that mutant KRAS in colorectal cancer cells has a limited role in modulating fibroblast pro-tumorigenic features, suggesting KRAS-independent mechanisms may drive fibroblast activation and resistance to KRAS inhibitors.
DOI 10.3390/cells11162490