Author

S. Vervoort

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

F. van Wijk· 2 shared J. Peeters· 2 shared J. van Loosdregt· 2 shared M. Mokry· 2 shared R. Scholman· 2 shared A. Boltjes· 1 shared A. C. Lewis· 1 shared A. M. N. Silva· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersImmunology

F. van Wijk

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Epigenetic changes in autoimmune monocytes contribute to disease and can be targeted by JAKinhibition

J. van Loosdregt, J. Peeters, A. Boltjes, R. Scholman, S. Vervoort, P. Coffer, M. Mokry, B. Vastert, F. van Wijk

The paper investigates epigenetic changes in monocytes from JIA patients and shows JAK inhibition can reverse disease-related gene expression.

bioRxiv · Nov 20, 2021 · PreprintImmunology

Inhibition of pyrimidine biosynthesis targets protein translation in AML.

L. M. Kats, J. So, A. C. Lewis, L. K. Smith, K. Stanley, L. Pijpers, P. Dominguez, S. J. Hogg, S. Vervoort, R. W. Johnstone, G. McDonald, D. B. Ulanet, J. Murtie, E. Gruber

This study shows that DHODH inhibitors block protein translation in AML by reducing YY1 and enhance AML treatment while sparing normal blood cells.

bioRxiv · Sep 24, 2021 · PreprintCancer Biology

Loss of erythroblasts in acute myeloid leukemia causes iron redistribution with clinical implications

M. Lopes, T. Duarte, M. J. Teles, L. Mosteo, S. Chacim, E. Aguiar, J. Pereira-Reis, M. Oliveira, A. M. N. Silva, N. Goncalves, G. Martins, I. Kong, M. Zethoven, S. Vervoort, S. Martins, , D. Duarte

The paper investigates iron metabolism in AML, finding that AML causes iron redistribution through erythroblast loss, leading to high TSAT and improved survival.

bioRxiv · Oct 26, 2020Cancer Biology

Conserved human effector Treg signature is reflected in transcriptomic and epigenetic landscape

G. Mijnheer, L. Lutter, M. Mokry, M. van der Wal, V. Fleskens, R. Scholman, A. Pandit, W. Tao, M. Wekking, S. Vervoort, C. Roberts, A. Petrelli, J. Peeters, M. Knijff, S. de Roock, , F. van Wijk

The paper identifies a conserved human effector Treg signature through transcriptomic and epigenetic analysis, showing overlap with tumor-infiltrating Treg and environment-driven adaptations.

bioRxiv · Sep 30, 2020 · PreprintImmunology