Author

E. Gruber

University Medical Center Utrecht

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

L. M. Kats· 3 shared R. W. Johnstone· 3 shared A. C. Lewis· 2 shared J. So· 2 shared K. Stanley· 2 shared A. E. Tron· 1 shared A. H. Wei· 1 shared A. J. Rogers· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCancer Biology

L. M. Kats

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Novel hepatocyte-like liver organoids recapitulate crucial mature hepatic functions

Arif Ibrahim Ardisasmita, Indi P. Joore, N. Levy, Adam Myszczyszyn, Ary Marsee, Theo L. Sinnige, Jos P.N. Ruiter, Sacha Ferdinandusse, Oksana Y. Dudaryeva, E. Gruber, V. Daive, Riccardo Levato, Bart Spee, Monique M. A. Verstegen, Luc J. W. van der Laan, , Sabine A. Fuchs

This study develops hepatocyte-like liver organoids (HeLLOs) that closely mimic mature hepatocyte functions and outperform existing models in drug toxicity testing and disease modeling.

bioRxiv · Oct 29, 2024 · PreprintCell Biology

Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells

E. Gruber, J. So, A. C. Lewis, R. Franich, R. Cole, L. G. Martelotto, A. J. Rogers, E. Vidacs, P. Fraser, K. Stanley, L. Jones, A. S. Trigos, N. Thio, J. Li, B. Nicolay, , L. M. Kats

This study shows that inhibiting mutant IDH1 in AML promotes leukemic stem cell cycling and sensitizes the disease to azacitidine, suggesting a combination therapy approach.

bioRxiv · Apr 6, 2022Cancer Biology

Inhibition of pyrimidine biosynthesis targets protein translation in AML.

L. M. Kats, J. So, A. C. Lewis, L. K. Smith, K. Stanley, L. Pijpers, P. Dominguez, S. J. Hogg, S. Vervoort, R. W. Johnstone, G. McDonald, D. B. Ulanet, J. Murtie, E. Gruber

This study shows that DHODH inhibitors block protein translation in AML by reducing YY1 and enhance AML treatment while sparing normal blood cells.

bioRxiv · Sep 24, 2021 · PreprintCancer Biology

A GATA6-centered gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancer

P. Martinelli, B. Kloesch, N. Hruschka, V. Ionasz, R. Oellinger, S. Mueller, J. Martinez de Villareal, H. P. Dienes, M. Schindl, E. Gruber, J. Stift, G. A. Lomberk, B. Seidler, D. Saur, R. Rad, , F. X. Real

This paper identifies a GATA6-centered gene regulatory network involving HNFs and ΔNp63 that controls plasticity and immune escape in pancreatic cancer, showing GATA6 loss is necessary but not sufficient for the basal phenotype.

Gut · Apr 12, 2021Peer-reviewedCancer Biology

Reprogramming of serine metabolism is an actionable vulnerability in FLT3-ITD driven acute myeloid leukaemia

S. Bjelosevic, E. Gruber, A. Newbold, L. M. Kats, C. Shembrey, T. C. Abrehart, I. Todorovski, G. Pomilio, A. H. Wei, G. P. Gregory, S. J. Vervoort, K. K. Brown, R. W. Johnstone

This study identifies serine metabolism as a vulnerability in FLT3-ITD AML, showing that targeting serine synthesis enhances chemotherapy efficacy.

Cancer Discovery · Jan 12, 2021Peer-reviewedCancer Biology