J. van Loosdregt

Glycolytic reprogramming shapes the epigenetic landscape of activated CD4+ T Cells in Juvenile Idiopathic Arthritis

This study shows that glycolytic reprogramming in JIA CD4+ T cells drives epigenetic changes linked to inflammation, with potential therapeutic implications.

Human regulatory T-cells locally differentiate and are functionally heterogeneous within the inflamed arthritic joint

This study identifies functional heterogeneity in human regulatory T-cells within inflamed arthritic joints using single-cell sequencing and flow cytometry.

Functional Specialization of Specific DC Subsets in the Synovial Fluid of JIA Patients

This study identifies functional specialization of dendritic cell subsets in synovial fluid of JIA patients, showing cDC2 and monocytes are pro-inflammatory while cDC1 remains quiescent.

Epigenetic changes in autoimmune monocytes contribute to disease and can be targeted by JAKinhibition

The paper investigates epigenetic changes in monocytes from JIA patients and shows JAK inhibition can reverse disease-related gene expression.

T cell derived HB-EGF prevents Th17 cell differentiation in an autocrine way.

The paper shows that HB-EGF expressed by CD4 T cells prevents Th17 differentiation and autoimmune disease by sustaining IL-2 expression.

Conserved human effector Treg signature is reflected in transcriptomic and epigenetic landscape

The paper identifies a conserved human effector Treg signature through transcriptomic and epigenetic analysis, showing overlap with tumor-infiltrating Treg and environment-driven adaptations.

Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells.

This study shows that KIF21B limits microtubule growth to enable rapid centrosome polarization in T cells by inducing microtubule pausing and catastrophe.