Author

S. de Roock

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

F. van Wijk· 2 shared A. Marson· 1 shared A. Pandit· 1 shared A. Petrelli· 1 shared C. Roberts· 1 shared D. R. Myers· 1 shared D. R. Simeonov· 1 shared G. Mijnheer· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

F. van Wijk

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Author profile →

2 papers

Recent·Most cited

Conserved human effector Treg signature is reflected in transcriptomic and epigenetic landscape

G. Mijnheer, L. Lutter, M. Mokry, M. van der Wal, V. Fleskens, R. Scholman, A. Pandit, W. Tao, M. Wekking, S. Vervoort, C. Roberts, A. Petrelli, J. Peeters, M. Knijff, S. de Roock, , F. van Wijk

The paper identifies a conserved human effector Treg signature through transcriptomic and epigenetic analysis, showing overlap with tumor-infiltrating Treg and environment-driven adaptations.

bioRxiv · Sep 30, 2020 · PreprintImmunology

Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity

M. Baars, T. Douma, D. R. Simeonov, D. R. Myers, S. Banerjee, K. Kulhanek, S. Zwakenberg, M. P. Baltissen, S. de Roock, F. van Wijk, M. Vermeulen, A. Marson, J. P. Roose, Y. Vercoulen

The paper shows that reduced RASGRP1 expression, regulated by RUNX1, contributes to autoimmunity by impairing T cell function and increasing inflammation.

bioRxiv · Nov 8, 2019Immunology