S. W. Manka

A structural basis for prion strain diversity

This paper determines the cryo-EM structure of ME7 prion fibrils and compares it to RML fibrils, revealing structural differences that explain prion strain diversity within the same species.

2.7 A cryo-EM structure of ex vivo RML prion fibrils

The paper presents a cryo-EM structure of prion fibrils from RML prion-infected mice, revealing structural features and conformational variations that may influence prion strain diversity and propagation.

Thermodynamic and mechanistic insights into coupled binding and unwinding of collagen by matrix metalloproteinase 1

This paper investigates the thermodynamics of collagen unwinding by MMP-1, finding that it involves a curved enthalpy-temperature relationship and structural strain relief upon cleavage.

Pseudo-repeats in doublecortin make distinct mechanistic contributions to microtubule regulation

This study uses cryo-EM and microscopy to show how different domains of doublecortin regulate microtubule nucleation and stabilization through distinct mechanisms.

Structural studies of MMP-3 interaction with triple-helical collagen introduce the enzyme’s new roles in tissue remodelling

This study identifies MMP-3 interaction sites on collagen II and III using triple-helical peptides, revealing cooperative binding between its catalytic and hemopexin domains.