Author

K. Aasumets

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Berner· 1 shared A. Bugai· 1 shared A. F. Arutyunyan· 1 shared A. Ianevski· 1 shared A. L. Zhuze· 1 shared A. Waage· 1 shared C. Heckman· 1 shared D. Bulanova· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCell Biology

A. Berner

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2 papers

Recent·Most cited

Enhanced mitochondrial G-quadruplex formation impedes replication fork progression leading to mtDNA loss in human cells

M. Doimo, S. Abrahamsson, V. L'Hote, M. Ndi, R. N. Das, K. Aasumets, A. Berner, S. Goffart, J. L. O. Pohjoismäki, M. Davila, E. Chorell, S. Wanrooij

The paper shows that mitochondrial DNA replication stalling increases G-quadruplex formation, which blocks replication forks and leads to mtDNA loss in human cells.

bioRxiv · Jun 8, 2022Cell Biology

Chemical, physical and biological triggers of Bcl-xL-mediated apoptosis

A. Ianevski, E. Kulesskiy, K. Krpina, G. Lou, Y. Aman, A. Bugai, K. Aasumets, Y. Akimov, D. Bulanova, K. Gildemann, A. F. Arutyunyan, O. Y. Susova, A. L. Zhuze, P. Ji, W. Wang, , D. E. Kainov

This study shows that Bcl-xL-specific inhibitors, when combined with DNA-damaging agents or physical insults, trigger apoptosis in various cell types and C. elegans by releasing Bad and Bax from Bcl-xL.

bioRxiv · Jan 13, 2020Cancer Biology