Author

S. Y. Kupke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

U. Reichl· 3 shared M. D. Hein· 2 shared Y. Genzel· 2 shared A. Chawla· 1 shared C. B. Brooke· 1 shared D. Bruder· 1 shared D. Ruediger· 1 shared F. G. Alnaji· 1 shared

Activity by Year

2021-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersEvolutionary Biology

U. Reichl

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Author profile →

3 papers

Recent·Most cited

Evolutionary BiologyJournal of VirologyPeer-reviewedNov 23, 2021

Semi-continuous propagation of influenza A virus and its defective interfering particles: analyzing the dynamic competition to select candidates for antiviral therapy

L. Pelz, D. Ruediger, T. Dogra…·U. Reichl

This study investigates the competition between influenza A virus and its defective interfering particles (DIPs) during co-infection, identifying DIPs with superior antiviral efficacy as potential therapeutic candidates.

DOI 10.1128/jvi.01174-21

humanbulk RNA-seq

𝕏 PostBluesky

BioengineeringbioRxivJun 7, 2021

Cell culture-based production of defective interfering influenza A virus particles in perfusion mode using an alternating tangential flow filtration system

M. D. Hein, A. Chawla, M. Cattaneo…·U. Reichl

This paper establishes an automated perfusion process for producing IAV DIPs using an alternating tangential flow filtration system, achieving high DIP titers and enabling continuous virus harvesting.

DOI 10.1007/s00253-021-11561-y

humanexperimental assay

𝕏 PostBluesky

MicrobiologybioRxivFeb 19, 2021

Antiviral activity of influenza A virus defective interfering particles against SARS-CoV-2 replication in vitro through stimulation of innate immunity

U. Rand, S. Y. Kupke, H. Shkarlet…·D. Bruder

This study shows that influenza A virus defective interfering particles inhibit SARS-CoV-2 replication in vitro by enhancing innate immunity through JAK/STAT signaling.

DOI 10.3390/cells10071756

humanexperimental assay

𝕏 PostBluesky